TY - JOUR
T1 - The number of microvascular complications is associated with an increased risk for severity of periodontitis in type 2 diabetes patients
T2 - Results of a multicenter hospital-based cross-sectional study
AU - Nitta, Hiroshi
AU - Katagiri, Sayaka
AU - Nagasawa, Toshiyuki
AU - Izumi, Yuichi
AU - Ishikawa, Isao
AU - Izumiyama, Hajime
AU - Uchimura, Isao
AU - Kanazawa, Masao
AU - Chiba, Hiroshige
AU - Matsuo, Akira
AU - Utsunomiya, Kazunori
AU - Tanabe, Haruyasu
AU - Takei, Izumi
AU - Asanami, Soichiro
AU - Kajio, Hiroshi
AU - Ono, Toaki
AU - Hayashi, Yoichi
AU - Ueki, Kiichi
AU - Tsuji, Masatomi
AU - Kurachi, Yoichi
AU - Yamanouchi, Toshikazu
AU - Ichinokawa, Yoshimi
AU - Inokuchi, Toshiki
AU - Fukui, Akiko
AU - Miyazaki, Shigeru
AU - Miyauchi, Takashi
AU - Kawahara, Reiko
AU - Ogiuchi, Hideki
AU - Yoshioka, Narihito
AU - Negishi, Jun
AU - Mori, Masatomo
AU - Mogi, Kenji
AU - Saito, Yasushi
AU - Tanzawa, Hideki
AU - Nishikawa, Tetsuo
AU - Takada, Norihiko
AU - Nanjo, Kishio
AU - Morita, Nobuo
AU - Nakamura, Naoto
AU - Kanamura, Narisato
AU - Makino, Hirofumi
AU - Nishimura, Fusanori
AU - Kobayashi, Kunihisa
AU - Higuchi, Yoshinori
AU - Sakata, Toshiie
AU - Yanagisawa, Shigetaka
AU - Tei, Chuwa
AU - Ando, Yuichi
AU - Hanada, Nobuhiro
AU - Inoue, Shuji
N1 - Funding Information:
This work was supported by Grants-in Aid from the Ministry of Health and Welfare of Japan (H16-Iryo-020), Mitsui Sumitomo Insurance Welfare Foundation, and 8020 Foundation.
Publisher Copyright:
© 2017 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd
PY - 2017/9
Y1 - 2017/9
N2 - Aims/Introduction: To explore the relationships between periodontitis and microvascular complications as well as glycemic control in type 2 diabetes patients. Materials and Methods: This multicenter, hospital-based, cross-sectional study included 620 patients with type 2 diabetes. We compared the prevalence and severity of periodontitis between patients with ≥1 microvascular complication and those without microvascular complications. We also compared the prevalence and severity of periodontitis among patients with different degrees of glycemic control. Results: After adjusting for confounding factors, multiple logistic regression analysis showed that the severity of periodontitis was significantly associated with the number of microvascular complications (odds ratio 1.3, 95% confidence interval 1.1–1.6), glycated hemoglobin ≥8.0% (64 mmol/mol; odds ratio 1.6; 95% confidence interval 1.1–2.3), and older age (≥50 years; odds ratio 1.7; 95% confidence interval 1.1–2.6). However, the prevalence of periodontitis was not significantly associated with the number of microvascular complications, but was associated with male sex, high glycated hemoglobin (≥8.0% [64 mmol/mol]), older age (≥40 years), longer duration of diabetes (≥15 years) and fewer teeth (≤25). Furthermore, propensity score matching for age, sex, diabetes duration and glycated hemoglobin showed that the incidence of severe periodontitis was significantly higher among patients with microvascular complications than among those without microvascular complications (P < 0.05). Conclusions: The number of microvascular complications is a risk factor for more severe periodontitis in patients with type 2 diabetes, whereas poor glycemic control is a risk factor for increased prevalence and severity of periodontitis.
AB - Aims/Introduction: To explore the relationships between periodontitis and microvascular complications as well as glycemic control in type 2 diabetes patients. Materials and Methods: This multicenter, hospital-based, cross-sectional study included 620 patients with type 2 diabetes. We compared the prevalence and severity of periodontitis between patients with ≥1 microvascular complication and those without microvascular complications. We also compared the prevalence and severity of periodontitis among patients with different degrees of glycemic control. Results: After adjusting for confounding factors, multiple logistic regression analysis showed that the severity of periodontitis was significantly associated with the number of microvascular complications (odds ratio 1.3, 95% confidence interval 1.1–1.6), glycated hemoglobin ≥8.0% (64 mmol/mol; odds ratio 1.6; 95% confidence interval 1.1–2.3), and older age (≥50 years; odds ratio 1.7; 95% confidence interval 1.1–2.6). However, the prevalence of periodontitis was not significantly associated with the number of microvascular complications, but was associated with male sex, high glycated hemoglobin (≥8.0% [64 mmol/mol]), older age (≥40 years), longer duration of diabetes (≥15 years) and fewer teeth (≤25). Furthermore, propensity score matching for age, sex, diabetes duration and glycated hemoglobin showed that the incidence of severe periodontitis was significantly higher among patients with microvascular complications than among those without microvascular complications (P < 0.05). Conclusions: The number of microvascular complications is a risk factor for more severe periodontitis in patients with type 2 diabetes, whereas poor glycemic control is a risk factor for increased prevalence and severity of periodontitis.
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U2 - 10.1111/jdi.12633
DO - 10.1111/jdi.12633
M3 - Article
C2 - 28129466
AN - SCOPUS:85013302732
VL - 8
SP - 677
EP - 686
JO - Journal of Diabetes Investigation
JF - Journal of Diabetes Investigation
SN - 2040-1116
IS - 5
ER -