The Oldest Japanese Case of Combined Central and Peripheral Demyelination, which Developed Nine Years after the First Instance of Optic Neuritis

Emi Nomura, Yuko Kawahara, Yoshio Omote, Koh Tadokoro, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Hidenori Ogata, Koji Abe

研究成果: Contribution to journalArticle査読

抄録

Combined central and peripheral demyelination (CCPD) causes demyelination in both the central and peripheral nervous systems. Anti-neurofascin 155 antibody plays an important pathogenic role in CCPD, but evidence concerning an association between this antibody and CCPD remains inconclusive. Although there have been no reports of precedent optic neuritis developing into CCPD, we herein report a Japanese man in whom optic neuritis recurred four times over nine years and who developed CCPD without positive anti-neurofascin 155 antibody. This case suggests the possibility of developing CCPD after optic nerve neuritis and the existence of an unknown antibody that induces CCPD.

本文言語英語
ページ(範囲)305-308
ページ数4
ジャーナルInternal Medicine
60
2
DOI
出版ステータス出版済み - 1 15 2021
外部発表はい

All Science Journal Classification (ASJC) codes

  • 内科学

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