The onset mechanism of primary Biliary cirrhosis

Shinji Shimoda

研究成果: Chapter in Book/Report/Conference proceedingChapter


The principal homologous antigen of antimitochondrial antibodies is pyruvate dehydrogenase complex E2 component (PDC-E2) which is present in the mitochondrial inner membrane. The involvement of autoimmunity is considered due to the presence of both autoreactive CD4-positive T cells and CD8-positive T cells recognizing PDC-E2. Autoreactive NK cells are also involved in bile duct damage and in addition to acquired immunity, abnormalities in innate immunity are also very important regarding the onset of PBC. In addition to the mechanism of the bile duct epithelial cells presenting autoantigens, the pathology of chronic nonsuppurative destructive cholangitis (CNSDC) is maintained by means of antigen-presenting cells such as dendritic cells, macrophages, etc., which present autoantigens discharged from damaged bile duct epithelial cells.

ホスト出版物のタイトルAutoimmune Liver Diseases
ホスト出版物のサブタイトルPerspectives from Japan
出版社Springer Japan
ISBN(印刷版)4431547886, 9784431547884
出版ステータス出版済み - 8 1 2014

All Science Journal Classification (ASJC) codes

  • 医学(全般)


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