The pace of evolution across fitness valleys

Chaitanya S. Gokhale, Yoh Iwasa, Martin A. Nowak, Arne Traulsen

研究成果: Contribution to journalArticle

32 引用 (Scopus)


How fast does a population evolve from one fitness peak to another? We study the dynamics of evolving, asexually reproducing populations in which a certain number of mutations jointly confer a fitness advantage. We consider the time until a population has evolved from one fitness peak to another one with a higher fitness. The order of mutations can either be fixed or random. If the order of mutations is fixed, then the population follows a metaphorical ridge, a single path. If the order of mutations is arbitrary, then there are many ways to evolve to the higher fitness state. We address the time required for fixation in such scenarios and study how it is affected by the order of mutations, the population size, the fitness values and the mutation rate.

ジャーナルJournal of Theoretical Biology
出版物ステータス出版済み - 8 7 2009

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Modelling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

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  • これを引用

    Gokhale, C. S., Iwasa, Y., Nowak, M. A., & Traulsen, A. (2009). The pace of evolution across fitness valleys. Journal of Theoretical Biology, 259(3), 613-620.