The photoreactivity of the caged precursors of oligonucleotides containing C4'-oxidized abasic site and reaction of the generated lesion.

Kazuteru Usui, Mariko Aso, Mitsuhiro Fukuda, Yukiko Toguchi, Hiroshi Suemune

研究成果: ジャーナルへの寄稿会談の抜粋

抄録

The C4'-oxidized abasic site (1) is one of the oxidatively damaged DNA lesions by antitumor bleomycins (BLMs) and the acyclic keto aldehyde incorporated in DNA might react with DNA interacting biomolecules. We synthesized oligodeoxynuceotides 3-caged-1 and 3-caged-2 as caged precursors of 3, an ODN containing 1, to study the reactivities of 3 with amine. Irradiation of double stranded 3-caged-1 led to efficient formation of 3 compared to its single stranded form. Similarly, 3-caged-2 and its duplex afforded 3. With 3-caged-2, yields of 3 were lower compared to 3-caged-1. Formation of the duplex slowed decaging rate down but the yield of 3 was higher than that of single stranded 3-cage-2. Reaction of the obtained 3 with amine resulted in the formation of lactam 2b in good yield.

元の言語英語
ページ(範囲)33-34
ページ数2
ジャーナルNucleic acids symposium series (2004)
発行部数51
出版物ステータス出版済み - 1 1 2007

Fingerprint

Oligonucleotides
Amines
DNA
Lactams
Bleomycin
Aldehydes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

これを引用

The photoreactivity of the caged precursors of oligonucleotides containing C4'-oxidized abasic site and reaction of the generated lesion. / Usui, Kazuteru; Aso, Mariko; Fukuda, Mitsuhiro; Toguchi, Yukiko; Suemune, Hiroshi.

:: Nucleic acids symposium series (2004), 番号 51, 01.01.2007, p. 33-34.

研究成果: ジャーナルへの寄稿会談の抜粋

@article{eee11ed9ba5e4055a1f3808cb1f61a11,
title = "The photoreactivity of the caged precursors of oligonucleotides containing C4'-oxidized abasic site and reaction of the generated lesion.",
abstract = "The C4'-oxidized abasic site (1) is one of the oxidatively damaged DNA lesions by antitumor bleomycins (BLMs) and the acyclic keto aldehyde incorporated in DNA might react with DNA interacting biomolecules. We synthesized oligodeoxynuceotides 3-caged-1 and 3-caged-2 as caged precursors of 3, an ODN containing 1, to study the reactivities of 3 with amine. Irradiation of double stranded 3-caged-1 led to efficient formation of 3 compared to its single stranded form. Similarly, 3-caged-2 and its duplex afforded 3. With 3-caged-2, yields of 3 were lower compared to 3-caged-1. Formation of the duplex slowed decaging rate down but the yield of 3 was higher than that of single stranded 3-cage-2. Reaction of the obtained 3 with amine resulted in the formation of lactam 2b in good yield.",
author = "Kazuteru Usui and Mariko Aso and Mitsuhiro Fukuda and Yukiko Toguchi and Hiroshi Suemune",
year = "2007",
month = "1",
day = "1",
language = "English",
pages = "33--34",
journal = "Nucleic acids symposium series (2004)",
issn = "1746-8272",
publisher = "Oxford University Press",
number = "51",

}

TY - JOUR

T1 - The photoreactivity of the caged precursors of oligonucleotides containing C4'-oxidized abasic site and reaction of the generated lesion.

AU - Usui, Kazuteru

AU - Aso, Mariko

AU - Fukuda, Mitsuhiro

AU - Toguchi, Yukiko

AU - Suemune, Hiroshi

PY - 2007/1/1

Y1 - 2007/1/1

N2 - The C4'-oxidized abasic site (1) is one of the oxidatively damaged DNA lesions by antitumor bleomycins (BLMs) and the acyclic keto aldehyde incorporated in DNA might react with DNA interacting biomolecules. We synthesized oligodeoxynuceotides 3-caged-1 and 3-caged-2 as caged precursors of 3, an ODN containing 1, to study the reactivities of 3 with amine. Irradiation of double stranded 3-caged-1 led to efficient formation of 3 compared to its single stranded form. Similarly, 3-caged-2 and its duplex afforded 3. With 3-caged-2, yields of 3 were lower compared to 3-caged-1. Formation of the duplex slowed decaging rate down but the yield of 3 was higher than that of single stranded 3-cage-2. Reaction of the obtained 3 with amine resulted in the formation of lactam 2b in good yield.

AB - The C4'-oxidized abasic site (1) is one of the oxidatively damaged DNA lesions by antitumor bleomycins (BLMs) and the acyclic keto aldehyde incorporated in DNA might react with DNA interacting biomolecules. We synthesized oligodeoxynuceotides 3-caged-1 and 3-caged-2 as caged precursors of 3, an ODN containing 1, to study the reactivities of 3 with amine. Irradiation of double stranded 3-caged-1 led to efficient formation of 3 compared to its single stranded form. Similarly, 3-caged-2 and its duplex afforded 3. With 3-caged-2, yields of 3 were lower compared to 3-caged-1. Formation of the duplex slowed decaging rate down but the yield of 3 was higher than that of single stranded 3-cage-2. Reaction of the obtained 3 with amine resulted in the formation of lactam 2b in good yield.

UR - http://www.scopus.com/inward/record.url?scp=42949115503&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=42949115503&partnerID=8YFLogxK

M3 - Meeting Abstract

SP - 33

EP - 34

JO - Nucleic acids symposium series (2004)

JF - Nucleic acids symposium series (2004)

SN - 1746-8272

IS - 51

ER -