The physiological role of mitophagy: New insights into phosphorylation events

Yuko Hirota, Dongchon Kang, Tomotake Kanki

研究成果: ジャーナルへの寄稿評論記事

33 引用 (Scopus)

抄録

Mitochondria play an essential role in oxidative phosphorylation, fatty acid oxidation, and the regulation of apoptosis. However, this organelle also produces reactive oxygen species (ROS) that continually inflict oxidative damage on mitochondrial DNA, proteins, and lipids, which causes further production of ROS. To oppose this oxidative stress, mitochondria possess quality control systems that include antioxidant enzymes and the repair or degradation of damaged mitochondrial DNA and proteins. If the oxidative stress exceeds the capacity of the mitochondrial quality control system, it seems that autophagy degrades the damaged mitochondria to maintain cellular homeostasis. Indeed, recent evidence from yeast to mammals indicates that the autophagy-dependent degradation of mitochondria (mitophagy) contributes to eliminate dysfunctional, aged, or excess mitochondria. In this paper, we describe the molecular processes and regulatory mechanisms of mitophagy in yeast and mammalian cells.

元の言語英語
記事番号354914
ジャーナルInternational Journal of Cell Biology
DOI
出版物ステータス出版済み - 4 19 2012

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Mitochondrial Degradation
Mitochondria
Phosphorylation
Mitochondrial Proteins
Autophagy
Mitochondrial DNA
Quality Control
Reactive Oxygen Species
Oxidative Stress
Yeasts
Oxidative Phosphorylation
Organelles
Mammals
Homeostasis
Fatty Acids
Antioxidants
Apoptosis
Lipids
Enzymes

All Science Journal Classification (ASJC) codes

  • Cell Biology

これを引用

The physiological role of mitophagy : New insights into phosphorylation events. / Hirota, Yuko; Kang, Dongchon; Kanki, Tomotake.

:: International Journal of Cell Biology, 19.04.2012.

研究成果: ジャーナルへの寄稿評論記事

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