The pleiotropic role of non-coding genes in development and cancer

Alessandra Pasut, Akinobu Matsumoto, John G. Clohessy, Pier Paolo Pandolfi

研究成果: Contribution to journalReview article査読

18 被引用数 (Scopus)

抄録

The expansive dimension of non-coding genes is by now a well-recognized feature of eukaryotes genomes. Over the past decades, in vitro functional studies and in vivo manipulation of non-coding genes through Genetically Engineered Mouse Models (GEMMs) have provided compelling evidence that almost every biological phenomenon is regulated, at some level, by non-coding RNA transcripts or by coding RNAs with non-coding functions. In this opinion article, we will discuss how recent discoveries in the field of non-coding RNAs are contributing to advance our understanding of evolution and organismal complexity and its relevance to human diseases.

本文言語英語
ページ(範囲)104-113
ページ数10
ジャーナルCurrent Opinion in Cell Biology
43
DOI
出版ステータス出版済み - 12 1 2016
外部発表はい

All Science Journal Classification (ASJC) codes

  • 細胞生物学

フィンガープリント

「The pleiotropic role of non-coding genes in development and cancer」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル