The preventive effects of mupirocin against nasotracheal intubation-related bacterial carriage

Satoshi Takahashi, Kouichiro Minami, Midori Ogawa, Hiroshi Miyamoto, Kunio Ikemura, Akio Shigematsu, Hatsumi Taniguchi

研究成果: ジャーナルへの寄稿記事

6 引用 (Scopus)

抜粋

Nasotracheal intubation is often required during dental and maxillofacial surgery. The complications of nasotracheal intubation are well documented, but there have been few systematic attempts to find methods for their prevention. We examined intubation-related carriage of bacteria, especially methicillin-resistant Staphylococcus aureus (MRSA), into the trachea and evaluated the effects of topical nasal treatment with mupirocin on intubation-related bacterial colonization. Of 38 patients without mupirocin treatment (nontreatment group), 27 (71.1%) showed general bacterial colonization in the nasal cavities before intubation. MRSA was isolated from 13.2% of the patients in this group. However, 10 of 22 patients (45%) treated with mupirocin (treatment group) showed colonization by general bacteria, and 2 (9%) were MRSA carriers before intubation. After nasal intubation, general bacteria and MRSA were isolated from the endotracheal tube tip in 66.2% and 16.7% of these patients in the nontreatment group, respectively. In contrast, general bacteria were isolated from the endotracheal tube tip in 19.2% of these patients after oral intubation, but no MRSA was detected. However, after nasal intubation, general bacteria were isolated from the endotracheal tube tip in 3 of the patients in the treatment group (23.1%), and no MRSA was detected, whereas no bacteria were isolated from oral intubation tubes. These results indicate that bacteria were carried into the trachea at a more frequent rate by nasal intubation as compared with oral intubation, and nasal treatment with mupirocin eliminated the nasal carriage of S. aureus. Topical nasal treatment with mupirocin before nasal intubation is thus suggested to be effective for preventing carriage of bacteria into the trachea.

元の言語英語
ページ(範囲)222-225
ページ数4
ジャーナルAnesthesia and Analgesia
97
発行部数1
DOI
出版物ステータス出版済み - 7 1 2003
外部発表Yes

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

これを引用

Takahashi, S., Minami, K., Ogawa, M., Miyamoto, H., Ikemura, K., Shigematsu, A., & Taniguchi, H. (2003). The preventive effects of mupirocin against nasotracheal intubation-related bacterial carriage. Anesthesia and Analgesia, 97(1), 222-225. https://doi.org/10.1213/01.ANE.0000066258.20778.06