The prognosis and the impact of radiotherapy in clinically regional lymph node-positive prostate cancer: Which patients are candidates for local therapy with radiation?

Kosuke Ieiri, Masaki Shiota, Eiji Kashiwagi, Ario Takeuchi, Ryosuke Takahashi, Junichi Inokuchi, Hidenori Iwai, Ken ichiro Shiga, Akira Yokomizo, Tadamasa Yoshitake, Yoshiyuki Shioyama, Kousei Ishigami, Hiromi Terashima, Masatoshi Eto

研究成果: Contribution to journalArticle査読

1 被引用数 (Scopus)

抄録

Background: This study aimed to identify the prognostic and predictive factors of local radiotherapy in clinically regional lymph node-positive prostate cancer. Patients and Methods: This study includes patients who were newly diagnosed with regional lymph node-positive prostate cancer between 2008 and 2017. We investigated the prognostic value of clinicopathological parameters for progression-free survival (PFS) and overall survival (OS) as well as the differential prognostic impact of radiotherapy by subgroup analysis. Results: Among the 93 men enrolled as patients, 48 (51.6 %) were treated with radiotherapy. The biopsy positive core rate and biopsy Gleason score were associated with PFS, and the number of lymph node metastases was associated with both PFS and OS. Patients who underwent radiotherapy showed better PFS and OS. High-risk features (at least 2 criteria among ≥75% biopsy positive core rate, Gleason score ≥9, and ≥2 positive lymph nodes) were especially associated with improved outcomes after undergoing radiotherapy. Conclusion: We identified prognostic factors for clinically regional lymph node-positive prostate cancer and showed the benefits of local radiation therapy. Patients with high-risk features may be especially suitable candidates for radiotherapy.

本文言語英語
ページ(範囲)931.e1-931.e7
ジャーナルUrologic Oncology: Seminars and Original Investigations
38
12
DOI
出版ステータス出版済み - 12 2020
外部発表はい

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 泌尿器学

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