The prognostic significance of blastemal predominant histology in initially resected Wilms' tumors: A report from the Study Group for Pediatric Solid Tumors in the Kyushu Area, Japan

Yoshiaki Kinoshita, Aiko Suminoe, Hiroko Inada, Minoru Yagi, Fumio Yanai, Yoshio Zaizen, Masanori Nishi, Yukihiro Inomata, Kiyoshi Kawakami, Hiroshi Matsufuji, Souichi Suenobu, Noritoshi Handa, Kenichi Kohashi, Yoshinao Oda, Toshiro Hara, Tomoaki Taguchi

研究成果: ジャーナルへの寄稿学術誌査読

18 被引用数 (Scopus)

抄録

Background and Purpose: The strategy used to treat pediatric renal tumors in Japan is based on the Japanese Wilms' Tumor Study (JWiTS) protocol, which was based on the National Wilms' Tumor Study (NWTS)-5 regimen. The regimen is characterized by an initial radical operation, followed by adjuvant chemotherapy and radiotherapy. Concerning the histological classification, a new classification based on the International Society of Pediatric Oncology (SIOP) classification was used beginning in 2008. The main points of revision are that the blastemal predominant type was classified as an independent category in the Wilms' tumor subtypes. The purpose of this study was to analyze the biological characteristics from the standpoint of the newly established histological classification. Materials and Methods: From 1971 to 2005, 174 cases of Wilms' tumors treated with an initial operation followed by adjuvant therapy were re-evaluated by the new histological classification. Histologically, all these materials showed no secondary changes associated with adjuvant therapy. Results: According to the new classification, Wilms' tumors were classified into four subtypes, including the mixed type (n = 112), epithelial type (n = 17), mesenchymal type (n = 15), and blastemal predominant type (n = 26). The 5 year overall survival rates were as follows; mixed type (90.1%), epithelial type (100%), mesenchymal type (93.3%), and blastemal predominant type (65.4%). Conclusion: The patients with blastemal predominant tumors demonstrated a significantly worse prognosis compared with those of other subtypes. The treatment strategy of blastemal predominant category should be distinguished from the other favorable subtypes.

本文言語英語
ページ(範囲)2205-2209
ページ数5
ジャーナルJournal of Pediatric Surgery
47
12
DOI
出版ステータス出版済み - 12月 2012
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 外科
  • 小児科学、周産期医学および子どもの健康

フィンガープリント

「The prognostic significance of blastemal predominant histology in initially resected Wilms' tumors: A report from the Study Group for Pediatric Solid Tumors in the Kyushu Area, Japan」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル