The promotion of invasion through the basement membrane of cervical carcinoma cells by fibronectin as a chemoattractant

Koichiro Sugihara, Toshiaki Saito, Masao Okadome, Kenzo Sonoda, Hiroaki Kobayashi, Toshiharu Kamura, Naoki Tsukamoto, Hitoo Nakano

研究成果: ジャーナルへの寄稿学術誌査読

7 被引用数 (Scopus)

抄録

An in vitro migration and invasion assay was used as the model system to study the effect of 3T3 fibroblast conditioned medium (FCM) and purified human fibronectin on the invasion of cervical carcinoma cells. The 3T3 FCM significantly enhanced both the migration and the invasion of a cervical carcinoma cell line, HeLa. This enhancement of migration and invasion was inhibited by anti-fibronectin antibody. Purified fibronectin alone enhanced the invasion in a dose-dependent manner for all cervical carcinoma cell lines, HeLa, CAC-1 and TMCC. The pretreatment of cells with cell binding aminosequences, GRGDSP and/or YIGSR blocked the enhancement of cell invasion. The implication of these findings for the invasion of cervical carcinoma is discussed.

本文言語英語
ページ(範囲)167-173
ページ数7
ジャーナルCancer Letters
79
2
DOI
出版ステータス出版済み - 5月 16 1994
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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