The RANKL/RANK system as a therapeutic target for bone invasion by oral squamous cell carcinoma (Review)

Eijiro Jimi, Masashi Shin, Hiroyuki Furuta, Yukiyo Tada, Jingo Kusukawa

研究成果: Contribution to journalReview article査読

30 被引用数 (Scopus)

抄録

Squamous cell carcinomas (SCCs) of the gingiva frequently invade the mandible or maxilla; this invasion is associated with a worse prognosis. The bone destruction associated with carcinomal invasion is mediated by osteoclasts rather than directly by the carcinoma. Therefore, if the cellular and molecular mechanisms by which oral SCC regulates bone invasion were known, it could inform the development of new therapeutic targets. Recently, dysregulation of the functional equilibrium in the receptor activator of NF-κB ligand (RANKL)/RANK/osteoprotegerin (OPG) triad has been shown to be responsible for osteolysis associated with the development of malignant tumors in bone sites. Furthermore, the administration of OPG or soluble RANK prevents bone metastasis by cancer cells. In this review, we discuss recent findings indicating that bone invasion by oral SCC is mediated via RANKL/RANK and may be successfully prevented by RANKL inhibition.

本文言語英語
ページ(範囲)803-809
ページ数7
ジャーナルInternational journal of oncology
42
3
DOI
出版ステータス出版済み - 3 2013
外部発表はい

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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