[The rapid analysis of polychlorinated quaterphenyls in blood using different diameter capillary column with the high-resolution gas chromatograph high-resolution mass spectrometer].

Daisuke Yasutake, Yuki Ashizuka, Tsuguhide Hori, Youichi Kurokawa, Jumboku Kajiwara, Teruaki Hirata, Yasuhisa Ishiguro, Takao Iida, Uchi Hiroshi, Masutaka Furue

研究成果: ジャーナルへの寄稿記事

抄録

The polychlorinated quaterphenyl (PCQ) concentrations in blood are important discriminative parameters in yusho patient. In this study, a rapid analytical method for PCQ using different diameter capillary column (rapid-Rtx65TG) with high-resolution gas chromatograph high-resolution mass spectrometer (HRGC/HRMS) instead of the gas chromatograph electron capture detector (ECD/GC) was developed. Using different diameter capillary columns, the analysis time of the HRGC/HRMS was drastically shortened, and the detection sensitivity was improved. In the rapid-Rtx65TG column, a small-bore capillary column (length 1m, I.D. 0.1mm) was connected with the inlet side of the GC, and behind that column, a large-bore capillary column (length 15mm, I.D. 0.53mm) for octadecachloroquaterphenyl (ODCQ) analysis was connected. In the HRGC/HRMS measurement of ODCQ by the rapid-Rtx65TG column, the minimum limit of detection for the apparatus was 0.4 pg, and the minimum limit of determination for the blood was 0.008 ppb. On ECD/GC in the conventional method and HRGC/HRMS in this study, the PCQ concentration in blood including yusho patients and yusho suspected persons was almost equivalent.

元の言語英語
ページ(範囲)145-152
ページ数8
ジャーナルFukuoka igaku zasshi = Hukuoka acta medica
102
発行部数4
出版物ステータス出版済み - 4 1 2011

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Gases
Limit of Detection
polychlorinated quaterphenyls
Electrons

All Science Journal Classification (ASJC) codes

  • Medicine(all)

これを引用

[The rapid analysis of polychlorinated quaterphenyls in blood using different diameter capillary column with the high-resolution gas chromatograph high-resolution mass spectrometer]. / Yasutake, Daisuke; Ashizuka, Yuki; Hori, Tsuguhide; Kurokawa, Youichi; Kajiwara, Jumboku; Hirata, Teruaki; Ishiguro, Yasuhisa; Iida, Takao; Hiroshi, Uchi; Furue, Masutaka.

:: Fukuoka igaku zasshi = Hukuoka acta medica, 巻 102, 番号 4, 01.04.2011, p. 145-152.

研究成果: ジャーナルへの寄稿記事

Yasutake, Daisuke ; Ashizuka, Yuki ; Hori, Tsuguhide ; Kurokawa, Youichi ; Kajiwara, Jumboku ; Hirata, Teruaki ; Ishiguro, Yasuhisa ; Iida, Takao ; Hiroshi, Uchi ; Furue, Masutaka. / [The rapid analysis of polychlorinated quaterphenyls in blood using different diameter capillary column with the high-resolution gas chromatograph high-resolution mass spectrometer]. :: Fukuoka igaku zasshi = Hukuoka acta medica. 2011 ; 巻 102, 番号 4. pp. 145-152.
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abstract = "The polychlorinated quaterphenyl (PCQ) concentrations in blood are important discriminative parameters in yusho patient. In this study, a rapid analytical method for PCQ using different diameter capillary column (rapid-Rtx65TG) with high-resolution gas chromatograph high-resolution mass spectrometer (HRGC/HRMS) instead of the gas chromatograph electron capture detector (ECD/GC) was developed. Using different diameter capillary columns, the analysis time of the HRGC/HRMS was drastically shortened, and the detection sensitivity was improved. In the rapid-Rtx65TG column, a small-bore capillary column (length 1m, I.D. 0.1mm) was connected with the inlet side of the GC, and behind that column, a large-bore capillary column (length 15mm, I.D. 0.53mm) for octadecachloroquaterphenyl (ODCQ) analysis was connected. In the HRGC/HRMS measurement of ODCQ by the rapid-Rtx65TG column, the minimum limit of detection for the apparatus was 0.4 pg, and the minimum limit of determination for the blood was 0.008 ppb. On ECD/GC in the conventional method and HRGC/HRMS in this study, the PCQ concentration in blood including yusho patients and yusho suspected persons was almost equivalent.",
author = "Daisuke Yasutake and Yuki Ashizuka and Tsuguhide Hori and Youichi Kurokawa and Jumboku Kajiwara and Teruaki Hirata and Yasuhisa Ishiguro and Takao Iida and Uchi Hiroshi and Masutaka Furue",
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AU - Hori, Tsuguhide

AU - Kurokawa, Youichi

AU - Kajiwara, Jumboku

AU - Hirata, Teruaki

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AU - Furue, Masutaka

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