The recognition of DNA binding molecules in the DNA strand exchange reaction

Aya Shintani, Nobu Tojyo, Asako Yamayoshi, Arihiro Kano, Atsushi Maruyama

研究成果: 会議への寄与タイプ学会誌査読

抄録

We have studied DNA strand exchange reactions (SERs) between double stranded (ds) DNA and single-stranded (ss) DNA. Recently, we have demonstrated that cationic comb-type copolymers (CCCs) accelerated the SER by more than four orders. It is widely known that DNA binding ligands can change the structures and the properties of DNAs in a sequence-dependent or -independent manner. Then we have studied the influence of these ligands on the kinetics of the DNA strand exchange reaction. Though either Distamycin or Hoechst 33258 showed a minor effect on the DNA melting, these ligands significantly affected on the kinetics of the SER. This might suggest that we could analyze DNA binding ligands using the SER.

本文言語英語
ページ4991-4992
ページ数2
出版ステータス出版済み - 12月 1 2006
外部発表はい
イベント55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, 日本
継続期間: 9月 20 20069月 22 2006

その他

その他55th Society of Polymer Science Japan Symposium on Macromolecules
国/地域日本
CityToyama
Period9/20/069/22/06

All Science Journal Classification (ASJC) codes

  • 工学(全般)

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