The recognition of DNA binding molecules in the DNA strand exchange reaction

Aya Shintani; Nobu Tojyo; Asako Yamayoshi; Arihiro Kano; Atsushi Maruyama

The recognition of DNA binding molecules in the DNA strand exchange reaction

Aya Shintani, Nobu Tojyo, Asako Yamayoshi, Arihiro Kano, Atsushi Maruyama

研究成果: 会議への寄与タイプ › 学会誌 › 査読

抄録

We have studied DNA strand exchange reactions (SERs) between double stranded (ds) DNA and single-stranded (ss) DNA. Recently, we have demonstrated that cationic comb-type copolymers (CCCs) accelerated the SER by more than four orders. It is widely known that DNA binding ligands can change the structures and the properties of DNAs in a sequence-dependent or -independent manner. Then we have studied the influence of these ligands on the kinetics of the DNA strand exchange reaction. Though either Distamycin or Hoechst 33258 showed a minor effect on the DNA melting, these ligands significantly affected on the kinetics of the SER. This might suggest that we could analyze DNA binding ligands using the SER.

本文言語	英語
ページ	4991-4992
ページ数	2
出版ステータス	出版済み - 12月 1 2006
外部発表	はい
イベント	55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, 日本継続期間: 9月 20 2006 → 9月 22 2006

その他

その他	55th Society of Polymer Science Japan Symposium on Macromolecules
国/地域	日本
City	Toyama
Period	9/20/06 → 9/22/06

All Science Journal Classification (ASJC) codes

工学（全般）

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title = "The recognition of DNA binding molecules in the DNA strand exchange reaction",

abstract = "We have studied DNA strand exchange reactions (SERs) between double stranded (ds) DNA and single-stranded (ss) DNA. Recently, we have demonstrated that cationic comb-type copolymers (CCCs) accelerated the SER by more than four orders. It is widely known that DNA binding ligands can change the structures and the properties of DNAs in a sequence-dependent or -independent manner. Then we have studied the influence of these ligands on the kinetics of the DNA strand exchange reaction. Though either Distamycin or Hoechst 33258 showed a minor effect on the DNA melting, these ligands significantly affected on the kinetics of the SER. This might suggest that we could analyze DNA binding ligands using the SER.",

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T1 - The recognition of DNA binding molecules in the DNA strand exchange reaction

AU - Shintani, Aya

AU - Tojyo, Nobu

AU - Yamayoshi, Asako

AU - Kano, Arihiro

AU - Maruyama, Atsushi

PY - 2006/12/1

Y1 - 2006/12/1

N2 - We have studied DNA strand exchange reactions (SERs) between double stranded (ds) DNA and single-stranded (ss) DNA. Recently, we have demonstrated that cationic comb-type copolymers (CCCs) accelerated the SER by more than four orders. It is widely known that DNA binding ligands can change the structures and the properties of DNAs in a sequence-dependent or -independent manner. Then we have studied the influence of these ligands on the kinetics of the DNA strand exchange reaction. Though either Distamycin or Hoechst 33258 showed a minor effect on the DNA melting, these ligands significantly affected on the kinetics of the SER. This might suggest that we could analyze DNA binding ligands using the SER.

AB - We have studied DNA strand exchange reactions (SERs) between double stranded (ds) DNA and single-stranded (ss) DNA. Recently, we have demonstrated that cationic comb-type copolymers (CCCs) accelerated the SER by more than four orders. It is widely known that DNA binding ligands can change the structures and the properties of DNAs in a sequence-dependent or -independent manner. Then we have studied the influence of these ligands on the kinetics of the DNA strand exchange reaction. Though either Distamycin or Hoechst 33258 showed a minor effect on the DNA melting, these ligands significantly affected on the kinetics of the SER. This might suggest that we could analyze DNA binding ligands using the SER.

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M3 - Paper

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T2 - 55th Society of Polymer Science Japan Symposium on Macromolecules

Y2 - 20 September 2006 through 22 September 2006

ER -

The recognition of DNA binding molecules in the DNA strand exchange reaction

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All Science Journal Classification (ASJC) codes

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