The recognition of DNA binding molecules in the DNA strand exchange reaction

Aya Shintani; Nobu Tojyo; Asako Yamayoshi; Arihiro Kano; Atsushi Maruyama

The recognition of DNA binding molecules in the DNA strand exchange reaction

Aya Shintani, Nobu Tojyo, Asako Yamayoshi, Arihiro Kano, Atsushi Maruyama

研究成果: Contribution to conference › Paper › 査読

抄録

We have studied DNA strand exchange reactions (SERs) between double stranded (ds) DNA and single-stranded (ss) DNA. Recently, we have demonstrated that cationic comb-type copolymers (CCCs) accelerated the SER by more than four orders. It is widely known that DNA binding ligands can change the structures and the properties of DNAs in a sequence-dependent or -independent manner. Then we have studied the influence of these ligands on the kinetics of the DNA strand exchange reaction. Though either Distamycin or Hoechst 33258 showed a minor effect on the DNA melting, these ligands significantly affected on the kinetics of the SER. This might suggest that we could analyze DNA binding ligands using the SER.

本文言語	英語
ページ	4991-4992
ページ数	2
出版ステータス	出版済み - 12 1 2006
外部発表	はい
イベント	55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, 日本継続期間: 9 20 2006 → 9 22 2006

その他

その他	55th Society of Polymer Science Japan Symposium on Macromolecules
Country	日本
City	Toyama
Period	9/20/06 → 9/22/06

All Science Journal Classification (ASJC) codes

Engineering(all)

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引用スタイル

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abstract = "We have studied DNA strand exchange reactions (SERs) between double stranded (ds) DNA and single-stranded (ss) DNA. Recently, we have demonstrated that cationic comb-type copolymers (CCCs) accelerated the SER by more than four orders. It is widely known that DNA binding ligands can change the structures and the properties of DNAs in a sequence-dependent or -independent manner. Then we have studied the influence of these ligands on the kinetics of the DNA strand exchange reaction. Though either Distamycin or Hoechst 33258 showed a minor effect on the DNA melting, these ligands significantly affected on the kinetics of the SER. This might suggest that we could analyze DNA binding ligands using the SER.",

author = "Aya Shintani and Nobu Tojyo and Asako Yamayoshi and Arihiro Kano and Atsushi Maruyama",

year = "2006",

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T1 - The recognition of DNA binding molecules in the DNA strand exchange reaction

AU - Shintani, Aya

AU - Tojyo, Nobu

AU - Yamayoshi, Asako

AU - Kano, Arihiro

AU - Maruyama, Atsushi

PY - 2006/12/1

Y1 - 2006/12/1

N2 - We have studied DNA strand exchange reactions (SERs) between double stranded (ds) DNA and single-stranded (ss) DNA. Recently, we have demonstrated that cationic comb-type copolymers (CCCs) accelerated the SER by more than four orders. It is widely known that DNA binding ligands can change the structures and the properties of DNAs in a sequence-dependent or -independent manner. Then we have studied the influence of these ligands on the kinetics of the DNA strand exchange reaction. Though either Distamycin or Hoechst 33258 showed a minor effect on the DNA melting, these ligands significantly affected on the kinetics of the SER. This might suggest that we could analyze DNA binding ligands using the SER.

AB - We have studied DNA strand exchange reactions (SERs) between double stranded (ds) DNA and single-stranded (ss) DNA. Recently, we have demonstrated that cationic comb-type copolymers (CCCs) accelerated the SER by more than four orders. It is widely known that DNA binding ligands can change the structures and the properties of DNAs in a sequence-dependent or -independent manner. Then we have studied the influence of these ligands on the kinetics of the DNA strand exchange reaction. Though either Distamycin or Hoechst 33258 showed a minor effect on the DNA melting, these ligands significantly affected on the kinetics of the SER. This might suggest that we could analyze DNA binding ligands using the SER.

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T2 - 55th Society of Polymer Science Japan Symposium on Macromolecules

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