The relation between serum endostatin level and carotid atherosclerosis in healthy residents of Japan: Results from the kyushu and okinawa population study (KOPS)

Yoshifumi Kato, Norihiro Furusyo, Yuuki Tanaka, Takatsugu Ueyama, Sho Yamasaki, Masayuki Murata, Jun Hayashi

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

抄録

Aim: To examine the association between the serum endostatin levels and subclinical atherosclerosis independent of traditional risk factors in a healthy Japanese population. Methods: Among 1,057 residents who attended free public physical examinations between 2010 and 2011, we evaluated the data of 648 healthy residents for whom the serum endostatin level and common carotid intima-media thickness (IMT) were successfully measured. Results: The median endostatin level was 63.7 ng/mL (interquartile ranges: 49.7.93.2 ng/mL), and the mean carotid IMT was 0.68±0.12 mm. Residents with above median endostatin had significantly higher carotid IMT than did those with below median endostatin (0.71±0.14 vs. 0.65±0.09 mm, P<0.001). Multiple linear regression analysis demonstrated that increased serum endostatin is significantly associated with carotid IMT (above vs. below median endostatin level; beta = 0.11, P = 0.03), independent of the known covariates of age, sex, body mass index, drinking and smoking status, systolic blood pressure, diastolic blood pressure, hemoglobin A1c, low density lipoprotein cholesterol, estimated glomerular filtration rate, and log-transformed high sensitive C-reactive protein. Conclusions: A higher serum endostatin level reflected subclinical atherosclerosis in this Japanese population.

元の言語英語
ページ(範囲)1023-1030
ページ数8
ジャーナルJournal of atherosclerosis and thrombosis
24
発行部数10
DOI
出版物ステータス出版済み - 1 1 2017

Fingerprint

Endostatins
Carotid Artery Diseases
Japan
Carotid Intima-Media Thickness
Serum
Population
Blood Pressure
Blood pressure
Atherosclerosis
Glomerular Filtration Rate
Linear regression
Regression analysis
C-Reactive Protein
LDL Cholesterol
Drinking
Physical Examination
Linear Models
Hemoglobins
Body Mass Index
Smoking

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Biochemistry, medical

これを引用

The relation between serum endostatin level and carotid atherosclerosis in healthy residents of Japan : Results from the kyushu and okinawa population study (KOPS). / Kato, Yoshifumi; Furusyo, Norihiro; Tanaka, Yuuki; Ueyama, Takatsugu; Yamasaki, Sho; Murata, Masayuki; Hayashi, Jun.

:: Journal of atherosclerosis and thrombosis, 巻 24, 番号 10, 01.01.2017, p. 1023-1030.

研究成果: ジャーナルへの寄稿記事

Kato, Yoshifumi ; Furusyo, Norihiro ; Tanaka, Yuuki ; Ueyama, Takatsugu ; Yamasaki, Sho ; Murata, Masayuki ; Hayashi, Jun. / The relation between serum endostatin level and carotid atherosclerosis in healthy residents of Japan : Results from the kyushu and okinawa population study (KOPS). :: Journal of atherosclerosis and thrombosis. 2017 ; 巻 24, 番号 10. pp. 1023-1030.
@article{94ca926f9a9d4f5c9197a132dfdd1f8e,
title = "The relation between serum endostatin level and carotid atherosclerosis in healthy residents of Japan: Results from the kyushu and okinawa population study (KOPS)",
abstract = "Aim: To examine the association between the serum endostatin levels and subclinical atherosclerosis independent of traditional risk factors in a healthy Japanese population. Methods: Among 1,057 residents who attended free public physical examinations between 2010 and 2011, we evaluated the data of 648 healthy residents for whom the serum endostatin level and common carotid intima-media thickness (IMT) were successfully measured. Results: The median endostatin level was 63.7 ng/mL (interquartile ranges: 49.7.93.2 ng/mL), and the mean carotid IMT was 0.68±0.12 mm. Residents with above median endostatin had significantly higher carotid IMT than did those with below median endostatin (0.71±0.14 vs. 0.65±0.09 mm, P<0.001). Multiple linear regression analysis demonstrated that increased serum endostatin is significantly associated with carotid IMT (above vs. below median endostatin level; beta = 0.11, P = 0.03), independent of the known covariates of age, sex, body mass index, drinking and smoking status, systolic blood pressure, diastolic blood pressure, hemoglobin A1c, low density lipoprotein cholesterol, estimated glomerular filtration rate, and log-transformed high sensitive C-reactive protein. Conclusions: A higher serum endostatin level reflected subclinical atherosclerosis in this Japanese population.",
author = "Yoshifumi Kato and Norihiro Furusyo and Yuuki Tanaka and Takatsugu Ueyama and Sho Yamasaki and Masayuki Murata and Jun Hayashi",
year = "2017",
month = "1",
day = "1",
doi = "10.5551/jat.39735",
language = "English",
volume = "24",
pages = "1023--1030",
journal = "Journal of Atherosclerosis and Thrombosis",
issn = "1340-3478",
publisher = "Japan Atherosclerosis Society",
number = "10",

}

TY - JOUR

T1 - The relation between serum endostatin level and carotid atherosclerosis in healthy residents of Japan

T2 - Results from the kyushu and okinawa population study (KOPS)

AU - Kato, Yoshifumi

AU - Furusyo, Norihiro

AU - Tanaka, Yuuki

AU - Ueyama, Takatsugu

AU - Yamasaki, Sho

AU - Murata, Masayuki

AU - Hayashi, Jun

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Aim: To examine the association between the serum endostatin levels and subclinical atherosclerosis independent of traditional risk factors in a healthy Japanese population. Methods: Among 1,057 residents who attended free public physical examinations between 2010 and 2011, we evaluated the data of 648 healthy residents for whom the serum endostatin level and common carotid intima-media thickness (IMT) were successfully measured. Results: The median endostatin level was 63.7 ng/mL (interquartile ranges: 49.7.93.2 ng/mL), and the mean carotid IMT was 0.68±0.12 mm. Residents with above median endostatin had significantly higher carotid IMT than did those with below median endostatin (0.71±0.14 vs. 0.65±0.09 mm, P<0.001). Multiple linear regression analysis demonstrated that increased serum endostatin is significantly associated with carotid IMT (above vs. below median endostatin level; beta = 0.11, P = 0.03), independent of the known covariates of age, sex, body mass index, drinking and smoking status, systolic blood pressure, diastolic blood pressure, hemoglobin A1c, low density lipoprotein cholesterol, estimated glomerular filtration rate, and log-transformed high sensitive C-reactive protein. Conclusions: A higher serum endostatin level reflected subclinical atherosclerosis in this Japanese population.

AB - Aim: To examine the association between the serum endostatin levels and subclinical atherosclerosis independent of traditional risk factors in a healthy Japanese population. Methods: Among 1,057 residents who attended free public physical examinations between 2010 and 2011, we evaluated the data of 648 healthy residents for whom the serum endostatin level and common carotid intima-media thickness (IMT) were successfully measured. Results: The median endostatin level was 63.7 ng/mL (interquartile ranges: 49.7.93.2 ng/mL), and the mean carotid IMT was 0.68±0.12 mm. Residents with above median endostatin had significantly higher carotid IMT than did those with below median endostatin (0.71±0.14 vs. 0.65±0.09 mm, P<0.001). Multiple linear regression analysis demonstrated that increased serum endostatin is significantly associated with carotid IMT (above vs. below median endostatin level; beta = 0.11, P = 0.03), independent of the known covariates of age, sex, body mass index, drinking and smoking status, systolic blood pressure, diastolic blood pressure, hemoglobin A1c, low density lipoprotein cholesterol, estimated glomerular filtration rate, and log-transformed high sensitive C-reactive protein. Conclusions: A higher serum endostatin level reflected subclinical atherosclerosis in this Japanese population.

UR - http://www.scopus.com/inward/record.url?scp=85030688111&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85030688111&partnerID=8YFLogxK

U2 - 10.5551/jat.39735

DO - 10.5551/jat.39735

M3 - Article

C2 - 28428451

AN - SCOPUS:85030688111

VL - 24

SP - 1023

EP - 1030

JO - Journal of Atherosclerosis and Thrombosis

JF - Journal of Atherosclerosis and Thrombosis

SN - 1340-3478

IS - 10

ER -