The relation of postprandial plasma glucose and serum endostatin to the urinary albumin excretion of residents with prediabetes

results from the Kyushu and Okinawa Population Study (KOPS)

Motohiro Shimizu, Norihiro Furusyo, Yuuki Tanaka, Yoshifumi Kato, Fujiko Mitsumoto-Kaseida, Koji Takayama, Kazuya Ura, Satoshi Hiramine, Takeo Hayashi, Hiroaki Ikezaki, Takeshi Ihara, Haru Mukae, Eiichi Ogawa, Kazuhiro Toyoda, Mosaburo Kainuma, Murata Masayuki, Jun Hayashi

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

抄録

Background: Previous clinical studies have shown that the circulating level of endostatin is related to kidney injury. We hypothesized that the impact of HbA1c, fasting, and postprandial plasma glucose on urinary albumin excretion would be related to the serum endostatin level. Methods: A cross-sectional, community-based population study of 1057 Japanese residents was conducted. Of these subjects, 162 with a fasting plasma glucose value between 5.5 and 6.9 mmol/L and an HbA1c level of <6.5 % received an oral glucose tolerance test, had serum endostatin measured, and had the urinary albumin/creatinine ratio (UACR) calculated. Results: In multivariate analysis, 2-h postprandial plasma glucose (β = 0.26, P < 0.01) was significantly associated with log-transformed UACR, independently of fasting plasma glucose (β = 0.14, P = 0.28) and HbA1c (β = −0.08, P = 0.57). When divided by the median value of endostatin (82.2 ng/mL), 2-h postprandial plasma glucose (β = 0.38, P = 0.01) remained significantly associated with the log-transformed UACR of the participants below the median, while the fasting plasma glucose (β = 0.34, P = 0.046) was independently associated with the log-transformed UACR of participants above the median. Conclusion: Postprandial plasma glucose was independently associated with the urinary albumin excretion of the residents with prediabetes. Moreover, this relationship was limited to residents with a serum endostatin level below the median.

元の言語英語
ページ(範囲)851-857
ページ数7
ジャーナルInternational Urology and Nephrology
48
発行部数6
DOI
出版物ステータス出版済み - 6 1 2016

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Endostatins
Prediabetic State
Albumins
Glucose
Serum
Fasting
Creatinine
Population
Glucose Tolerance Test
Multivariate Analysis
Kidney
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Urology

これを引用

The relation of postprandial plasma glucose and serum endostatin to the urinary albumin excretion of residents with prediabetes : results from the Kyushu and Okinawa Population Study (KOPS). / Shimizu, Motohiro; Furusyo, Norihiro; Tanaka, Yuuki; Kato, Yoshifumi; Mitsumoto-Kaseida, Fujiko; Takayama, Koji; Ura, Kazuya; Hiramine, Satoshi; Hayashi, Takeo; Ikezaki, Hiroaki; Ihara, Takeshi; Mukae, Haru; Ogawa, Eiichi; Toyoda, Kazuhiro; Kainuma, Mosaburo; Masayuki, Murata; Hayashi, Jun.

:: International Urology and Nephrology, 巻 48, 番号 6, 01.06.2016, p. 851-857.

研究成果: ジャーナルへの寄稿記事

Shimizu, Motohiro ; Furusyo, Norihiro ; Tanaka, Yuuki ; Kato, Yoshifumi ; Mitsumoto-Kaseida, Fujiko ; Takayama, Koji ; Ura, Kazuya ; Hiramine, Satoshi ; Hayashi, Takeo ; Ikezaki, Hiroaki ; Ihara, Takeshi ; Mukae, Haru ; Ogawa, Eiichi ; Toyoda, Kazuhiro ; Kainuma, Mosaburo ; Masayuki, Murata ; Hayashi, Jun. / The relation of postprandial plasma glucose and serum endostatin to the urinary albumin excretion of residents with prediabetes : results from the Kyushu and Okinawa Population Study (KOPS). :: International Urology and Nephrology. 2016 ; 巻 48, 番号 6. pp. 851-857.
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abstract = "Background: Previous clinical studies have shown that the circulating level of endostatin is related to kidney injury. We hypothesized that the impact of HbA1c, fasting, and postprandial plasma glucose on urinary albumin excretion would be related to the serum endostatin level. Methods: A cross-sectional, community-based population study of 1057 Japanese residents was conducted. Of these subjects, 162 with a fasting plasma glucose value between 5.5 and 6.9 mmol/L and an HbA1c level of <6.5 {\%} received an oral glucose tolerance test, had serum endostatin measured, and had the urinary albumin/creatinine ratio (UACR) calculated. Results: In multivariate analysis, 2-h postprandial plasma glucose (β = 0.26, P < 0.01) was significantly associated with log-transformed UACR, independently of fasting plasma glucose (β = 0.14, P = 0.28) and HbA1c (β = −0.08, P = 0.57). When divided by the median value of endostatin (82.2 ng/mL), 2-h postprandial plasma glucose (β = 0.38, P = 0.01) remained significantly associated with the log-transformed UACR of the participants below the median, while the fasting plasma glucose (β = 0.34, P = 0.046) was independently associated with the log-transformed UACR of participants above the median. Conclusion: Postprandial plasma glucose was independently associated with the urinary albumin excretion of the residents with prediabetes. Moreover, this relationship was limited to residents with a serum endostatin level below the median.",
author = "Motohiro Shimizu and Norihiro Furusyo and Yuuki Tanaka and Yoshifumi Kato and Fujiko Mitsumoto-Kaseida and Koji Takayama and Kazuya Ura and Satoshi Hiramine and Takeo Hayashi and Hiroaki Ikezaki and Takeshi Ihara and Haru Mukae and Eiichi Ogawa and Kazuhiro Toyoda and Mosaburo Kainuma and Murata Masayuki and Jun Hayashi",
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T1 - The relation of postprandial plasma glucose and serum endostatin to the urinary albumin excretion of residents with prediabetes

T2 - results from the Kyushu and Okinawa Population Study (KOPS)

AU - Shimizu, Motohiro

AU - Furusyo, Norihiro

AU - Tanaka, Yuuki

AU - Kato, Yoshifumi

AU - Mitsumoto-Kaseida, Fujiko

AU - Takayama, Koji

AU - Ura, Kazuya

AU - Hiramine, Satoshi

AU - Hayashi, Takeo

AU - Ikezaki, Hiroaki

AU - Ihara, Takeshi

AU - Mukae, Haru

AU - Ogawa, Eiichi

AU - Toyoda, Kazuhiro

AU - Kainuma, Mosaburo

AU - Masayuki, Murata

AU - Hayashi, Jun

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Background: Previous clinical studies have shown that the circulating level of endostatin is related to kidney injury. We hypothesized that the impact of HbA1c, fasting, and postprandial plasma glucose on urinary albumin excretion would be related to the serum endostatin level. Methods: A cross-sectional, community-based population study of 1057 Japanese residents was conducted. Of these subjects, 162 with a fasting plasma glucose value between 5.5 and 6.9 mmol/L and an HbA1c level of <6.5 % received an oral glucose tolerance test, had serum endostatin measured, and had the urinary albumin/creatinine ratio (UACR) calculated. Results: In multivariate analysis, 2-h postprandial plasma glucose (β = 0.26, P < 0.01) was significantly associated with log-transformed UACR, independently of fasting plasma glucose (β = 0.14, P = 0.28) and HbA1c (β = −0.08, P = 0.57). When divided by the median value of endostatin (82.2 ng/mL), 2-h postprandial plasma glucose (β = 0.38, P = 0.01) remained significantly associated with the log-transformed UACR of the participants below the median, while the fasting plasma glucose (β = 0.34, P = 0.046) was independently associated with the log-transformed UACR of participants above the median. Conclusion: Postprandial plasma glucose was independently associated with the urinary albumin excretion of the residents with prediabetes. Moreover, this relationship was limited to residents with a serum endostatin level below the median.

AB - Background: Previous clinical studies have shown that the circulating level of endostatin is related to kidney injury. We hypothesized that the impact of HbA1c, fasting, and postprandial plasma glucose on urinary albumin excretion would be related to the serum endostatin level. Methods: A cross-sectional, community-based population study of 1057 Japanese residents was conducted. Of these subjects, 162 with a fasting plasma glucose value between 5.5 and 6.9 mmol/L and an HbA1c level of <6.5 % received an oral glucose tolerance test, had serum endostatin measured, and had the urinary albumin/creatinine ratio (UACR) calculated. Results: In multivariate analysis, 2-h postprandial plasma glucose (β = 0.26, P < 0.01) was significantly associated with log-transformed UACR, independently of fasting plasma glucose (β = 0.14, P = 0.28) and HbA1c (β = −0.08, P = 0.57). When divided by the median value of endostatin (82.2 ng/mL), 2-h postprandial plasma glucose (β = 0.38, P = 0.01) remained significantly associated with the log-transformed UACR of the participants below the median, while the fasting plasma glucose (β = 0.34, P = 0.046) was independently associated with the log-transformed UACR of participants above the median. Conclusion: Postprandial plasma glucose was independently associated with the urinary albumin excretion of the residents with prediabetes. Moreover, this relationship was limited to residents with a serum endostatin level below the median.

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SN - 0301-1623

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