The Relationship between Water Structure and Blood Compatibility in Poly(2-methoxyethyl Acrylate) (PMEA) Analogues

Kazuhiro Sato, Shingo Kobayashi, Miho Kusakari, Shogo Watahiki, Masahiko Oikawa, Takashi Hoshiba, Masaru Tanaka

研究成果: ジャーナルへの寄稿記事

23 引用 (Scopus)

抄録

Six types of poly(2-methoxyethyl acrylate) (PMEA) analogues were synthesized and the water structure in the hydrated polymers was characterized using differential scanning calorimetry (DSC). The hydrated PMEA analogues exhibited the different amounts of intermediate water. Non-thrombogenicity evaluation was performed on PMEA analogues for platelet adhesion and protein adsorption. Platelet adhesion was suppressed on PMEA analogues. In addition, the protein adsorption and deformation were suppressed by increasing the amount of intermediate water. This study demonstrates that the amount of intermediate water might play a key role in expressing the blood compatibility of polymeric materials.

元の言語英語
ページ(範囲)1296-1303
ページ数8
ジャーナルMacromolecular Bioscience
15
発行部数9
DOI
出版物ステータス出版済み - 9 1 2015

Fingerprint

Blood
Water
Platelets
Adsorption
Blood Platelets
Adhesion
Proteins
Differential Scanning Calorimetry
Polymers
Differential scanning calorimetry
acrylic acid

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

これを引用

The Relationship between Water Structure and Blood Compatibility in Poly(2-methoxyethyl Acrylate) (PMEA) Analogues. / Sato, Kazuhiro; Kobayashi, Shingo; Kusakari, Miho; Watahiki, Shogo; Oikawa, Masahiko; Hoshiba, Takashi; Tanaka, Masaru.

:: Macromolecular Bioscience, 巻 15, 番号 9, 01.09.2015, p. 1296-1303.

研究成果: ジャーナルへの寄稿記事

Sato, Kazuhiro ; Kobayashi, Shingo ; Kusakari, Miho ; Watahiki, Shogo ; Oikawa, Masahiko ; Hoshiba, Takashi ; Tanaka, Masaru. / The Relationship between Water Structure and Blood Compatibility in Poly(2-methoxyethyl Acrylate) (PMEA) Analogues. :: Macromolecular Bioscience. 2015 ; 巻 15, 番号 9. pp. 1296-1303.
@article{99b98369d2464c03a272f383a2b8be09,
title = "The Relationship between Water Structure and Blood Compatibility in Poly(2-methoxyethyl Acrylate) (PMEA) Analogues",
abstract = "Six types of poly(2-methoxyethyl acrylate) (PMEA) analogues were synthesized and the water structure in the hydrated polymers was characterized using differential scanning calorimetry (DSC). The hydrated PMEA analogues exhibited the different amounts of intermediate water. Non-thrombogenicity evaluation was performed on PMEA analogues for platelet adhesion and protein adsorption. Platelet adhesion was suppressed on PMEA analogues. In addition, the protein adsorption and deformation were suppressed by increasing the amount of intermediate water. This study demonstrates that the amount of intermediate water might play a key role in expressing the blood compatibility of polymeric materials.",
author = "Kazuhiro Sato and Shingo Kobayashi and Miho Kusakari and Shogo Watahiki and Masahiko Oikawa and Takashi Hoshiba and Masaru Tanaka",
year = "2015",
month = "9",
day = "1",
doi = "10.1002/mabi.201500078",
language = "English",
volume = "15",
pages = "1296--1303",
journal = "Macromolecular Bioscience",
issn = "1616-5187",
publisher = "Wiley-VCH Verlag",
number = "9",

}

TY - JOUR

T1 - The Relationship between Water Structure and Blood Compatibility in Poly(2-methoxyethyl Acrylate) (PMEA) Analogues

AU - Sato, Kazuhiro

AU - Kobayashi, Shingo

AU - Kusakari, Miho

AU - Watahiki, Shogo

AU - Oikawa, Masahiko

AU - Hoshiba, Takashi

AU - Tanaka, Masaru

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Six types of poly(2-methoxyethyl acrylate) (PMEA) analogues were synthesized and the water structure in the hydrated polymers was characterized using differential scanning calorimetry (DSC). The hydrated PMEA analogues exhibited the different amounts of intermediate water. Non-thrombogenicity evaluation was performed on PMEA analogues for platelet adhesion and protein adsorption. Platelet adhesion was suppressed on PMEA analogues. In addition, the protein adsorption and deformation were suppressed by increasing the amount of intermediate water. This study demonstrates that the amount of intermediate water might play a key role in expressing the blood compatibility of polymeric materials.

AB - Six types of poly(2-methoxyethyl acrylate) (PMEA) analogues were synthesized and the water structure in the hydrated polymers was characterized using differential scanning calorimetry (DSC). The hydrated PMEA analogues exhibited the different amounts of intermediate water. Non-thrombogenicity evaluation was performed on PMEA analogues for platelet adhesion and protein adsorption. Platelet adhesion was suppressed on PMEA analogues. In addition, the protein adsorption and deformation were suppressed by increasing the amount of intermediate water. This study demonstrates that the amount of intermediate water might play a key role in expressing the blood compatibility of polymeric materials.

UR - http://www.scopus.com/inward/record.url?scp=84940796696&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84940796696&partnerID=8YFLogxK

U2 - 10.1002/mabi.201500078

DO - 10.1002/mabi.201500078

M3 - Article

C2 - 26017931

AN - SCOPUS:84940796696

VL - 15

SP - 1296

EP - 1303

JO - Macromolecular Bioscience

JF - Macromolecular Bioscience

SN - 1616-5187

IS - 9

ER -