TY - JOUR
T1 - The renin-angiotensin system in acute respiratory distress syndrome
AU - Imai, Yumiko
AU - Kuba, Keiji
AU - Penninger, Josef M.
N1 - Funding Information:
We thank Chengyu Jiang, Shuan Rao and many others for their contributions. Supported by grants from The National Bank of Austria, The Austrian Ministry of Science and Education, Institute of Molecular Biotechnology in Austrian Academy of Sciences (IMBA) and EUGeneHeart to J.M.P. K.K. is supported by a Marie Curie Fellowship from the EU.
PY - 2006
Y1 - 2006
N2 - Angiotensin-converting enzyme 2 (ACE2) counterbalances with ACE and functions as a negative regulator of the renin-angiotensin system (RAS). The importance of RAS in acute respiratory distress syndrome (ARDS) has recently re-emerged owing to the identification of ACE2 as a receptor for the SARS-coronavirus. Recent studies have demonstrated that ACE2 protects mice from acute lung injury as well as SARS-mediated lung injury. We review the role of the RAS, in particular ACE2, in the pathogenesis of ARDS.
AB - Angiotensin-converting enzyme 2 (ACE2) counterbalances with ACE and functions as a negative regulator of the renin-angiotensin system (RAS). The importance of RAS in acute respiratory distress syndrome (ARDS) has recently re-emerged owing to the identification of ACE2 as a receptor for the SARS-coronavirus. Recent studies have demonstrated that ACE2 protects mice from acute lung injury as well as SARS-mediated lung injury. We review the role of the RAS, in particular ACE2, in the pathogenesis of ARDS.
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U2 - 10.1016/j.ddmec.2006.06.012
DO - 10.1016/j.ddmec.2006.06.012
M3 - Review article
AN - SCOPUS:33748497602
SN - 1740-6765
VL - 3
SP - 225
EP - 229
JO - Drug Discovery Today: Disease Mechanisms
JF - Drug Discovery Today: Disease Mechanisms
IS - 2
ER -