The replication timing program in the hands of two HDACs

Kazumasa Yoshida, Armelle Lengronne, Philippe Pasero

研究成果: Contribution to journalReview article査読

1 被引用数 (Scopus)


In eukaryotes, duplication of genomic information depends on the sequential activation of multiple replication origins distributed along the chromosomes. Replication origins differ in initiation time, chromatin structure and three-dimensional position in the nucleus. Recently, we have performed a systematic analysis of the role of histone deacetylases (HDACs) in the regulation of origin activity in budding yeast. We have found that the epigenetic regulation of repetitive sequences is a key determinant of the DNA replication program. Indeed, our study revealed that two histone deacetylases, Rpd3 and Sir2, have opposite effects on the replication timing program. Rpd3 delays initiation at late origins, whereas Sir2 promotes efficient activation of early origins. Remarkably, we also found that Rpd3 and Sir2 regulate initiation at ~200 replication origins located within the ribosomal DNA (rDNA) array. We propose that this epigenetic regulation of repetitive origins controls the replication timing program by modulating the availability of limiting initiation factors.

ジャーナルMicrobial Cell
出版ステータス出版済み - 8 2014

All Science Journal Classification (ASJC) codes

  • 免疫学および微生物学(その他)
  • 生化学、遺伝学、分子生物学(その他)


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