The role of ERCP in the era of EUS-FNA for preoperative cytological confirmation of resectable pancreatic ductal adenocarcinoma

Takao Ohtsuka, Koji Tamura, Noboru Ideno, Teppei Aso, Yosuke Nagayoshi, Hiroshi Kono, Junji Ueda, Shunichi Takahata, Akira Aso, Hisato Igarashi, Tetsuhide Ito, Yasuhiro Ushijima, Fumihiko Ookubo, Yoshinao Oda, Kazuhiro Mizumoto, Masao Tanaka

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)

抄録

Purpose: In patients with pancreatic ductal carcinoma (PDAC), EUS-FNA carries a risk of cancer seeding. To avoid this risk, we attempted to obtain preoperative cytological confirmation of adenocarcinoma by ERCP. The aim of this study was to assess the validity of our diagnostic strategy.

Methods: The medical records of 124 consecutive patients who were investigated for potentially resectable PDAC were retrospectively reviewed, and the ability to detect adenocarcinoma by ERCP was evaluated.

Results: ERCP was performed in 115 patients, 69 of whom had positive cytology results. Thirty-four patients underwent EUS-FNA, 29 of whom had positive cytology results. A total of 98 patients (79 %), therefore, had preoperative cytological confirmation of adenocarcinoma, which was more frequent in patients with lesions of the head of the pancreas than in those with lesions of the body or tail of the pancreas. The postoperative pathological diagnosis demonstrated malignant pancreatic neoplasms in 122 patients (98 %), including 111 with PDAC. EUS-FNA did not affect the rate of postoperative peritoneal dissemination.

Conclusions: Our strategy using ERCP as the initial diagnostic modality for obtaining cytological confirmation of potentially resectable PDAC seems to be adequate, yielding a high rate of positive cytology, especially in cases with tumors of the head of the pancreas.

元の言語英語
ページ(範囲)1887-1892
ページ数6
ジャーナルSurgery today
44
発行部数10
DOI
出版物ステータス出版済み - 1 1 2014

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Endoscopic Ultrasound-Guided Fine Needle Aspiration
Endoscopic Retrograde Cholangiopancreatography
Pancreatic Ductal Carcinoma
Adenocarcinoma
Cell Biology
Pancreas
Pancreatic Neoplasms
Medical Records
Neoplasms

All Science Journal Classification (ASJC) codes

  • Surgery

これを引用

The role of ERCP in the era of EUS-FNA for preoperative cytological confirmation of resectable pancreatic ductal adenocarcinoma. / Ohtsuka, Takao; Tamura, Koji; Ideno, Noboru; Aso, Teppei; Nagayoshi, Yosuke; Kono, Hiroshi; Ueda, Junji; Takahata, Shunichi; Aso, Akira; Igarashi, Hisato; Ito, Tetsuhide; Ushijima, Yasuhiro; Ookubo, Fumihiko; Oda, Yoshinao; Mizumoto, Kazuhiro; Tanaka, Masao.

:: Surgery today, 巻 44, 番号 10, 01.01.2014, p. 1887-1892.

研究成果: ジャーナルへの寄稿記事

Ohtsuka, T, Tamura, K, Ideno, N, Aso, T, Nagayoshi, Y, Kono, H, Ueda, J, Takahata, S, Aso, A, Igarashi, H, Ito, T, Ushijima, Y, Ookubo, F, Oda, Y, Mizumoto, K & Tanaka, M 2014, 'The role of ERCP in the era of EUS-FNA for preoperative cytological confirmation of resectable pancreatic ductal adenocarcinoma', Surgery today, 巻. 44, 番号 10, pp. 1887-1892. https://doi.org/10.1007/s00595-014-0845-0
Ohtsuka, Takao ; Tamura, Koji ; Ideno, Noboru ; Aso, Teppei ; Nagayoshi, Yosuke ; Kono, Hiroshi ; Ueda, Junji ; Takahata, Shunichi ; Aso, Akira ; Igarashi, Hisato ; Ito, Tetsuhide ; Ushijima, Yasuhiro ; Ookubo, Fumihiko ; Oda, Yoshinao ; Mizumoto, Kazuhiro ; Tanaka, Masao. / The role of ERCP in the era of EUS-FNA for preoperative cytological confirmation of resectable pancreatic ductal adenocarcinoma. :: Surgery today. 2014 ; 巻 44, 番号 10. pp. 1887-1892.
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abstract = "Purpose: In patients with pancreatic ductal carcinoma (PDAC), EUS-FNA carries a risk of cancer seeding. To avoid this risk, we attempted to obtain preoperative cytological confirmation of adenocarcinoma by ERCP. The aim of this study was to assess the validity of our diagnostic strategy.Methods: The medical records of 124 consecutive patients who were investigated for potentially resectable PDAC were retrospectively reviewed, and the ability to detect adenocarcinoma by ERCP was evaluated.Results: ERCP was performed in 115 patients, 69 of whom had positive cytology results. Thirty-four patients underwent EUS-FNA, 29 of whom had positive cytology results. A total of 98 patients (79 {\%}), therefore, had preoperative cytological confirmation of adenocarcinoma, which was more frequent in patients with lesions of the head of the pancreas than in those with lesions of the body or tail of the pancreas. The postoperative pathological diagnosis demonstrated malignant pancreatic neoplasms in 122 patients (98 {\%}), including 111 with PDAC. EUS-FNA did not affect the rate of postoperative peritoneal dissemination.Conclusions: Our strategy using ERCP as the initial diagnostic modality for obtaining cytological confirmation of potentially resectable PDAC seems to be adequate, yielding a high rate of positive cytology, especially in cases with tumors of the head of the pancreas.",
author = "Takao Ohtsuka and Koji Tamura and Noboru Ideno and Teppei Aso and Yosuke Nagayoshi and Hiroshi Kono and Junji Ueda and Shunichi Takahata and Akira Aso and Hisato Igarashi and Tetsuhide Ito and Yasuhiro Ushijima and Fumihiko Ookubo and Yoshinao Oda and Kazuhiro Mizumoto and Masao Tanaka",
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T1 - The role of ERCP in the era of EUS-FNA for preoperative cytological confirmation of resectable pancreatic ductal adenocarcinoma

AU - Ohtsuka, Takao

AU - Tamura, Koji

AU - Ideno, Noboru

AU - Aso, Teppei

AU - Nagayoshi, Yosuke

AU - Kono, Hiroshi

AU - Ueda, Junji

AU - Takahata, Shunichi

AU - Aso, Akira

AU - Igarashi, Hisato

AU - Ito, Tetsuhide

AU - Ushijima, Yasuhiro

AU - Ookubo, Fumihiko

AU - Oda, Yoshinao

AU - Mizumoto, Kazuhiro

AU - Tanaka, Masao

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Purpose: In patients with pancreatic ductal carcinoma (PDAC), EUS-FNA carries a risk of cancer seeding. To avoid this risk, we attempted to obtain preoperative cytological confirmation of adenocarcinoma by ERCP. The aim of this study was to assess the validity of our diagnostic strategy.Methods: The medical records of 124 consecutive patients who were investigated for potentially resectable PDAC were retrospectively reviewed, and the ability to detect adenocarcinoma by ERCP was evaluated.Results: ERCP was performed in 115 patients, 69 of whom had positive cytology results. Thirty-four patients underwent EUS-FNA, 29 of whom had positive cytology results. A total of 98 patients (79 %), therefore, had preoperative cytological confirmation of adenocarcinoma, which was more frequent in patients with lesions of the head of the pancreas than in those with lesions of the body or tail of the pancreas. The postoperative pathological diagnosis demonstrated malignant pancreatic neoplasms in 122 patients (98 %), including 111 with PDAC. EUS-FNA did not affect the rate of postoperative peritoneal dissemination.Conclusions: Our strategy using ERCP as the initial diagnostic modality for obtaining cytological confirmation of potentially resectable PDAC seems to be adequate, yielding a high rate of positive cytology, especially in cases with tumors of the head of the pancreas.

AB - Purpose: In patients with pancreatic ductal carcinoma (PDAC), EUS-FNA carries a risk of cancer seeding. To avoid this risk, we attempted to obtain preoperative cytological confirmation of adenocarcinoma by ERCP. The aim of this study was to assess the validity of our diagnostic strategy.Methods: The medical records of 124 consecutive patients who were investigated for potentially resectable PDAC were retrospectively reviewed, and the ability to detect adenocarcinoma by ERCP was evaluated.Results: ERCP was performed in 115 patients, 69 of whom had positive cytology results. Thirty-four patients underwent EUS-FNA, 29 of whom had positive cytology results. A total of 98 patients (79 %), therefore, had preoperative cytological confirmation of adenocarcinoma, which was more frequent in patients with lesions of the head of the pancreas than in those with lesions of the body or tail of the pancreas. The postoperative pathological diagnosis demonstrated malignant pancreatic neoplasms in 122 patients (98 %), including 111 with PDAC. EUS-FNA did not affect the rate of postoperative peritoneal dissemination.Conclusions: Our strategy using ERCP as the initial diagnostic modality for obtaining cytological confirmation of potentially resectable PDAC seems to be adequate, yielding a high rate of positive cytology, especially in cases with tumors of the head of the pancreas.

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