The role of nuclear Y-box binding protein 1 as a global marker in drug resistance

Michihiko Kuwano, Yoshinao Oda, Hiroto Izumi, Song Ju Yang, Takeshi Uchiumi, Yukihide Iwamoto, Masakazu Toi, Teruhiko Fujii, Hideaki Yamana, Hisafumi Kinoshita, Toshiharu Kamura, Masazumi Tsuneyoshi, Kosei Yasumoto, Kimitoshi Kohno

研究成果: ジャーナルへの寄稿簡易調査査読

124 被引用数 (Scopus)


Gene expression can be regulated by nuclear factors at the transcriptional level. Many such factors regulate MDR1 gene expression, but what are the sequence elements and transcription factors that control the basal and inducible expression of this gene? The general principles through which transcription factors participate in drug resistance are now beginning to be understood. Here, we review the factors involved in the transcriptional regulation of the MDR1 gene. In particular, we focus on the transcription factor Y-box binding protein 1 and discuss the possible links between Y-box binding protein 1 expression and drug resistance in cancer, which are mediated by the transmembrane P-glycoprotein or non - P-glycoprotein.

ジャーナルMolecular cancer therapeutics
出版ステータス出版済み - 11月 2004

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究


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