The role of prostacyclin in patients with portal hypertension

Makoto Hashizume, Kiyoshi Inokuchi, Kenzo Tanaka

研究成果: ジャーナルへの寄稿記事

15 引用 (Scopus)

抄録

ABSTRACT— The serum levels of prostacyclin in portal venous blood samples from patients with portal hypertension were measured by radioimmunoassay to assess the role of prostacyclin in this clinical entity. Portal venous prostacyclin activity exceeded peripheral venous activity 2–3 fold in both cirrhotics and non‐cirrhotics. The size of esophageal varices showed an inverse relation to the concentration of portal venous prostacyclin in the cirrhotics. There was no significant difference between the portal vein pressure and the size of varices, and the portal vein pressure did not correlate with the concentration of 6 keto‐PGF1a. Thus, serum levels of portal venous prostacyclin may depend on the development of collateral circulation in cirrhotics and increased splanchnic blood flow probably accelerates the washout effect.

元の言語英語
ページ(範囲)89-93
ページ数5
ジャーナルLiver
5
発行部数2
DOI
出版物ステータス出版済み - 1 1 1985

Fingerprint

Portal Hypertension
Epoprostenol
Portal Pressure
Portal Vein
Collateral Circulation
Viscera
Esophageal and Gastric Varices
Varicose Veins
Serum
Radioimmunoassay

All Science Journal Classification (ASJC) codes

  • Hepatology

これを引用

The role of prostacyclin in patients with portal hypertension. / Hashizume, Makoto; Inokuchi, Kiyoshi; Tanaka, Kenzo.

:: Liver, 巻 5, 番号 2, 01.01.1985, p. 89-93.

研究成果: ジャーナルへの寄稿記事

Hashizume, M, Inokuchi, K & Tanaka, K 1985, 'The role of prostacyclin in patients with portal hypertension', Liver, 巻. 5, 番号 2, pp. 89-93. https://doi.org/10.1111/j.1600-0676.1985.tb00220.x
Hashizume, Makoto ; Inokuchi, Kiyoshi ; Tanaka, Kenzo. / The role of prostacyclin in patients with portal hypertension. :: Liver. 1985 ; 巻 5, 番号 2. pp. 89-93.
@article{b1da4f4d0570456b880c28c55ff6b64f,
title = "The role of prostacyclin in patients with portal hypertension",
abstract = "ABSTRACT— The serum levels of prostacyclin in portal venous blood samples from patients with portal hypertension were measured by radioimmunoassay to assess the role of prostacyclin in this clinical entity. Portal venous prostacyclin activity exceeded peripheral venous activity 2–3 fold in both cirrhotics and non‐cirrhotics. The size of esophageal varices showed an inverse relation to the concentration of portal venous prostacyclin in the cirrhotics. There was no significant difference between the portal vein pressure and the size of varices, and the portal vein pressure did not correlate with the concentration of 6 keto‐PGF1a. Thus, serum levels of portal venous prostacyclin may depend on the development of collateral circulation in cirrhotics and increased splanchnic blood flow probably accelerates the washout effect.",
author = "Makoto Hashizume and Kiyoshi Inokuchi and Kenzo Tanaka",
year = "1985",
month = "1",
day = "1",
doi = "10.1111/j.1600-0676.1985.tb00220.x",
language = "English",
volume = "5",
pages = "89--93",
journal = "Liver International",
issn = "1478-3223",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - The role of prostacyclin in patients with portal hypertension

AU - Hashizume, Makoto

AU - Inokuchi, Kiyoshi

AU - Tanaka, Kenzo

PY - 1985/1/1

Y1 - 1985/1/1

N2 - ABSTRACT— The serum levels of prostacyclin in portal venous blood samples from patients with portal hypertension were measured by radioimmunoassay to assess the role of prostacyclin in this clinical entity. Portal venous prostacyclin activity exceeded peripheral venous activity 2–3 fold in both cirrhotics and non‐cirrhotics. The size of esophageal varices showed an inverse relation to the concentration of portal venous prostacyclin in the cirrhotics. There was no significant difference between the portal vein pressure and the size of varices, and the portal vein pressure did not correlate with the concentration of 6 keto‐PGF1a. Thus, serum levels of portal venous prostacyclin may depend on the development of collateral circulation in cirrhotics and increased splanchnic blood flow probably accelerates the washout effect.

AB - ABSTRACT— The serum levels of prostacyclin in portal venous blood samples from patients with portal hypertension were measured by radioimmunoassay to assess the role of prostacyclin in this clinical entity. Portal venous prostacyclin activity exceeded peripheral venous activity 2–3 fold in both cirrhotics and non‐cirrhotics. The size of esophageal varices showed an inverse relation to the concentration of portal venous prostacyclin in the cirrhotics. There was no significant difference between the portal vein pressure and the size of varices, and the portal vein pressure did not correlate with the concentration of 6 keto‐PGF1a. Thus, serum levels of portal venous prostacyclin may depend on the development of collateral circulation in cirrhotics and increased splanchnic blood flow probably accelerates the washout effect.

UR - http://www.scopus.com/inward/record.url?scp=0021881118&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021881118&partnerID=8YFLogxK

U2 - 10.1111/j.1600-0676.1985.tb00220.x

DO - 10.1111/j.1600-0676.1985.tb00220.x

M3 - Article

C2 - 3889532

AN - SCOPUS:0021881118

VL - 5

SP - 89

EP - 93

JO - Liver International

JF - Liver International

SN - 1478-3223

IS - 2

ER -