The role of pulmonary metastasectomy for hepatoblastoma in children with metastasis at diagnosis: Results from the JPLT-2 study

Tomoro Hishiki, Kenichiro Watanabe, Kohmei Ida, Ken Hoshino, Tomoko Iehara, Yuki Aoki, Takuro Kazama, Kentaro Kihira, Yuichi Takama, Tomoaki Taguchi, Junya Fujimura, Shohei Honda, Kimikazu Matsumoto, Makiko Mori, Michihiro Yano, Akiko Yokoi, Yukichi Tanaka, Hiroshi Fuji, Osamu Miyazaki, Kenichi YoshimuraTetsuya Takimoto, Eiso Hiyama

研究成果: Contribution to journalArticle査読

21 被引用数 (Scopus)

抄録

Background/purpose The purpose of this study was to clarify the role of pulmonary metastasectomy in hepatoblastomas with lung metastasis at diagnosis. We reviewed cases enrolled in the JPLT-2 study. Methods A total of 360 cases with hepatoblastoma were enrolled. The clinical courses and outcome of 60 cases with pulmonary metastasis at diagnosis were reviewed, focusing on metastasectomy. Results Induction chemotherapy resulted in eradication of nodules in 26, residual nodules in 33, and early treatment-related death in one. Of the 33 cases with residual nodules, 11 underwent complete resection of the lung lesions, and among these, progression was reported in five. Complete resection of the liver tumor was not achieved in two of these. Three underwent incomplete resection of lung nodules, eventually leading to progression. Twelve cases with incomplete or no liver tumor resection progressed regardless of the status of lung lesions. Contrarily, among patients who underwent complete resection of the liver tumor, half were cured without metastasectomy. Conclusions Metastasectomy for residual pulmonary nodules after induction chemotherapy is effective provided that the liver tumor could be completely resected. Type of study Prospective Cohort Study. Level of evidence Level II.

本文言語英語
ページ(範囲)2051-2055
ページ数5
ジャーナルJournal of Pediatric Surgery
52
12
DOI
出版ステータス出版済み - 12 2017

All Science Journal Classification (ASJC) codes

  • 小児科学、周産期医学および子どもの健康
  • 外科

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