The Schizosaccharomyces pombe gms1+ gene encodes an UDP-galactose transporter homologue required for protein galactosylation

Mitsuaki Tabuchi, Naotaka Tanaka, Shojiro Iwahara, Kaoru Takegawa

研究成果: ジャーナルへの寄稿学術誌査読

76 被引用数 (Scopus)

抄録

In a previous study, we isolated a Schizosaccharomyces pombe mutant defective in protein galactosylation. From an S. pombe genomic library, we cloned the gms1+ gene which restored the galactosylation of cell wall glycoproteins. Gms1 protein shares significant sequence similarity with human UDP-galactose and murine CMP-sialic acid transporters. The fission yeast strains deleted for the gms1+ gene lacked galactose residues in sell surface glycoproteins and were significantly decreased in UDP-galactose transport activity. These results showed that the gms1+ encodes an UDP-galactose transporter, and this protein appears to be an essential role for the incorporation of UDP-galactose into the lumen of Golgi in S. pombe.

本文言語英語
ページ(範囲)121-125
ページ数5
ジャーナルBiochemical and Biophysical Research Communications
232
1
DOI
出版ステータス出版済み - 3月 6 1997
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

フィンガープリント

「The Schizosaccharomyces pombe gms1+ gene encodes an UDP-galactose transporter homologue required for protein galactosylation」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル