The serotonin1A receptor agonist 8-OHDPAT reverses Δ9-tetrahydrocannabinol-induced impairment of spatial memory and reduction of acetylcholine release in the dorsal hippocampus in rats

Keiichiro Inui, Nobuaki Egashira, Kenichi Mishima, Akiko Yano, Yoshiaki Matsumoto, Nobuyoshi Hasebe, Kohji Abe, Kazuhide Hayakawa, Tomoaki Ikeda, Katsunori Iwasaki, Michihiro Fujiwara

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We studied the effects of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OHDPAT), a 5-HT1A receptor agonist, on both Δ9-tetrahydrocannabinol-induced spatial memory impairment in an 8-arm radial maze, and the reduction of acetylcholine release in the dorsal hippocampus as assessed by in vivo microdialysis in rats. A 6 mg/kg i.p. dose of Δ9-tetrahydrocannabinol impaired spatial memory in the 8-arm radial maze and decreased the acetyl-choline release in the dorsal hippocampus. 8-OHD-PAT, at very low doses of 0.1-0.3 μg/kg, reversed both the impairment of spatial memory and the decrease in acetylcholine release induced by Δ9-tetrahydrocannabinol. These findings suggest that low doses of 8-OHDPAT may improve Δ9 -tetrahy-drocannabinol-induced impairment of spatial memory by enhancing acetylcholine release in the dorsal hippocampus.

元の言語英語
ページ(範囲)153-157
ページ数5
ジャーナルNeurotoxicity Research
6
発行部数2
DOI
出版物ステータス出版済み - 2004
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Toxicology

フィンガープリント The serotonin<sub>1A</sub> receptor agonist 8-OHDPAT reverses Δ<sup>9</sup>-tetrahydrocannabinol-induced impairment of spatial memory and reduction of acetylcholine release in the dorsal hippocampus in rats' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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