The severity of obstructive sleep apnea syndrome cannot predict the accumulation of brain amyloid by imaging with [11C]-Pittsburgh compound B PET computed tomography in patients with a normal cognitive function

Sakiko Shimizu Handa, Shingo Baba, kenichiro yamashita, Mari Nishizaka, Shinichi Ando

研究成果: ジャーナルへの寄稿記事

抄録

Objective: Disturbed sleep due to obstructive sleep apnea syndrome (OSAS) might accelerate amyloidβ (Aβ) deposition, which can be a crucial factor in Alzheimer’s disease. We studied Aβ deposition in untreated OSAS patients with normal cognition. Method: We performed polysomnography (PSG) and Aβ imaging with [11C]-Pittsburgh compound B PET computed tomography (11C-PiB PET CT) in 14 untreated OSAS patients (apnea–hypopnea index: 43.8 ± 26.3/h). Results: The abnormal accumulation of enhanced 11C-PiB PET was observed only one patient with severe, but not the most severe. Conclusions: The OSAS severity alone may not predict Aβ deposition in OSAS patients with normal cognition.

元の言語英語
ページ(範囲)541-544
ページ数4
ジャーナルAnnals of Nuclear Medicine
33
発行部数7
DOI
出版物ステータス出版済み - 7 1 2019

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Obstructive Sleep Apnea
Amyloid
Neuroimaging
Cognition
Tomography
Polysomnography
Alzheimer Disease
Sleep
2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

これを引用

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abstract = "Objective: Disturbed sleep due to obstructive sleep apnea syndrome (OSAS) might accelerate amyloidβ (Aβ) deposition, which can be a crucial factor in Alzheimer’s disease. We studied Aβ deposition in untreated OSAS patients with normal cognition. Method: We performed polysomnography (PSG) and Aβ imaging with [11C]-Pittsburgh compound B PET computed tomography (11C-PiB PET CT) in 14 untreated OSAS patients (apnea–hypopnea index: 43.8 ± 26.3/h). Results: The abnormal accumulation of enhanced 11C-PiB PET was observed only one patient with severe, but not the most severe. Conclusions: The OSAS severity alone may not predict Aβ deposition in OSAS patients with normal cognition.",
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T1 - The severity of obstructive sleep apnea syndrome cannot predict the accumulation of brain amyloid by imaging with [11C]-Pittsburgh compound B PET computed tomography in patients with a normal cognitive function

AU - Handa, Sakiko Shimizu

AU - Baba, Shingo

AU - yamashita, kenichiro

AU - Nishizaka, Mari

AU - Ando, Shinichi

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