The solubility and stability of amino acids in biocompatible ionic liquids

T. Vasantha, Awanish Kumar, Pankaj Attri, Pannuru Venkatesu, R. S. Rama Devi

研究成果: Contribution to journalArticle査読

27 被引用数 (Scopus)

抄録

In recent years, ionic liquids (ILs) represent a new class of biocompatible co-solvents for biomolecules. In this work, we report the apparent transfer free energies (ΔG′tr) for six amino acids (AA) from water to aqueous solutions of six ammonium based ILs (diethylammonium acetate (DEAA), diethylammonium sulfate (DEAS), triethyl ammonium acetate (TEAA), triethylammonium sulfate (TEAS), triethylammonium dihydrogen phosphate (TEAP), and trimethylammonium acetate (TMAA)) through solubility measurements, as a function of IL concentration at 298.15 K under atmospheric pressure. Salting-out effect was found for AA in aqueous IL solutions with increasing IL concentrations. In addition, we observed positive values of ΔG′ tr for AA from water to ILs, indicating that the interactions between ILs and AA are unfavorable. From the obtained results, we found that the selected ammonium based ILs act as stabilizers for the structure of AA.

本文言語英語
ページ(範囲)15-24
ページ数10
ジャーナルProtein and Peptide Letters
21
1
DOI
出版ステータス出版済み - 1 2014
外部発表はい

All Science Journal Classification (ASJC) codes

  • 構造生物学
  • 生化学

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