The T cell receptor β chain genes are located on chromosome 6 in mice and chromosome 7 in humans

Nicolette Caccia, Mitchell Kronenberg, Debra Saxe, Regina Haars, Gail A.P. Bruns, Joan Goverman, Marie Malissen, Hunt Willard, Yasunobu Yoshikai, Melvin Simon, Leroy Hood, Tak W. Mak

研究成果: Contribution to journalArticle査読

131 被引用数 (Scopus)

抄録

Homologous clones that encode the β chain of the T cell antigen receptor have been isolated recently from both murine and human cDNA libraries. These cDNA clones have been used in connection with interspecies hybrid cell lines to determine that the murine T cell receptor gene is located on chromosome 6 and the human gene on chromosome 7. In situ hybridization confirms these data and further localizes these genes to band B of chromosome 6 in the mouse and bands 7p13-21 in the human genome. The organization of the T cell antigen receptor Jβ gene segments and Cβ genes appears to be conserved, since very few intraspecies polymorphisms of restriction fragment length have been detected in either mouse or human DNA.

本文言語英語
ページ(範囲)1091-1099
ページ数9
ジャーナルCell
37
3
DOI
出版ステータス出版済み - 7 1984
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学、遺伝学、分子生物学(全般)

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