The T cell receptor β chain genes are located on chromosome 6 in mice and chromosome 7 in humans

Nicolette Caccia, Mitchell Kronenberg, Debra Saxe, Regina Haars, Gail A.P. Bruns, Joan Goverman, Marie Malissen, Hunt Willard, Yasunobu Yoshikai, Melvin Simon, Leroy Hood, Tak W. Mak

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    Homologous clones that encode the β chain of the T cell antigen receptor have been isolated recently from both murine and human cDNA libraries. These cDNA clones have been used in connection with interspecies hybrid cell lines to determine that the murine T cell receptor gene is located on chromosome 6 and the human gene on chromosome 7. In situ hybridization confirms these data and further localizes these genes to band B of chromosome 6 in the mouse and bands 7p13-21 in the human genome. The organization of the T cell antigen receptor Jβ gene segments and Cβ genes appears to be conserved, since very few intraspecies polymorphisms of restriction fragment length have been detected in either mouse or human DNA.

    元の言語英語
    ページ(範囲)1091-1099
    ページ数9
    ジャーナルCell
    37
    発行部数3
    DOI
    出版物ステータス出版済み - 7 1984

    All Science Journal Classification (ASJC) codes

    • Biochemistry, Genetics and Molecular Biology(all)

    フィンガープリント The T cell receptor β chain genes are located on chromosome 6 in mice and chromosome 7 in humans' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Caccia, N., Kronenberg, M., Saxe, D., Haars, R., Bruns, G. A. P., Goverman, J., Malissen, M., Willard, H., Yoshikai, Y., Simon, M., Hood, L., & Mak, T. W. (1984). The T cell receptor β chain genes are located on chromosome 6 in mice and chromosome 7 in humans. Cell, 37(3), 1091-1099. https://doi.org/10.1016/0092-8674(84)90443-4