The Therapeutic Potential of Secreted Factors from Dental Pulp Stem Cells for Various Diseases

Kenichi Ogata, Masafumi Moriyama, Seiji Nakamura, Mayu Matsumura-Kawashima, Tatsuya Kawado, Aiko Yano

研究成果: ジャーナルへの寄稿総説査読

抄録

An alternative source of mesenchymal stem cells has recently been discovered: dental pulp stem cells (DPSCs), including deciduous teeth, which can thus comprise potential tools for regenerative medicine. DPSCs derive from the neural crest and are normally implicated in dentin homeostasis. The clinical application of mesenchymal stem cells (MSCs) involving DPSCs contains various limitations, such as high cost, low safety, and cell handling issues, as well as invasive sample collection procedures. Although MSCs implantation offers favorable outcomes on specific diseases, implanted MSCs cannot survive for a long period. It is thus considered that their mediated mechanism of action involves paracrine effects. It has been recently reported that secreted molecules in DPSCs-conditioned media (DPSC-CM) contain various trophic factors and cytokines and that DPSC-CM are effective in models of various diseases. In the current study, we focus on the characteristics of DPSC-CM and their therapeutic potential against various disorders.

本文言語英語
論文番号1049
ジャーナルBiomedicines
10
5
DOI
出版ステータス出版済み - 5月 2022

!!!All Science Journal Classification (ASJC) codes

  • 医学(その他)
  • 生化学、遺伝学、分子生物学(全般)

フィンガープリント

「The Therapeutic Potential of Secreted Factors from Dental Pulp Stem Cells for Various Diseases」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル