WarfarinとS-1併用患者における血液凝固能異常の発現時期に関する検討

山田 孝明, 渡邉 裕之, 矢野 貴久, 野中 敏治, 高田 敦史, 園田 正信, 窪田 敏夫, 江頭 伸昭, 大石 了三

研究成果: Contribution to journalArticle査読

抄録

  Although S-1 is frequently used in cancer chemotherapy, the drug interaction with warfarin, an anticoagulant agent, is not fully paid attention. In the present study, we investigated retrospectively the timing of expression of blood coagulation abnormality in nine patients treated with warfarin and S-1 concomitantly. In five patients, the dose of warfarin was reduced or interrupted after concomitant use of S-1. The International Normalized Ratio (INR) was significantly increased after combination with S-1 compared with the former value. In all patients, the INR was increased in three weeks after combination with S-1. On the other hand, serum creatinine, aspartate aminotransferase, alanine aminotransferase or serum albumin was not different before and after combination with S-1. These results suggest that the careful monitoring of the blood coagulation ability is necessary in all patients receiving warfarin and S-1 concomitantly.<br>
寄稿の翻訳タイトルThe Timing of Expression of Blood Coagulation Abnormality in Patients Treated with Warfarin and S-1 Concomitantly
本文言語日本語
ページ(範囲)955-960
ページ数6
ジャーナルYakugaku Zasshi
130
7
DOI
出版ステータス出版済み - 2010

フィンガープリント

「WarfarinとS-1併用患者における血液凝固能異常の発現時期に関する検討」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル