The treatment of rheumatoid arthritis with NF-kappaB inhibitors

Eijiro Jimi, Ichiro Nakamura

研究成果: Contribution to journalReview article査読

抄録

The nuclear factor kappaB (NF-kappaB) participates in the expression of a wide variety of genes that are involved in the regulation of host immune and inflammatory responses. In rheumatoid arthritis, the activation of NF-kappaB has been detected in synovium and lymphocytes, and induction of arthritis in mice produced strong NF-kappaB transcriptional activity in the affected joints. These evidences suggest that NF-kappaB is an interesting therapeutic target in rheumatoid arthritis. In this review, we are going to review briefly the signaling pathway that leads to NF-kappaB activation and then discuss the possibility that the inhibition of NF-kappaB might provide novel treatment to inhibit bone destruction in rheumatoid arthritis.

本文言語英語
ページ(範囲)1627-1632
ページ数6
ジャーナルNippon rinsho. Japanese journal of clinical medicine
63
9
出版ステータス出版済み - 1 1 2005
外部発表はい

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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