The utility of urinary myo-inositol as a marker of glucose intolerance

Hiroaki Ikezaki, Norihiro Furusyo, Kyoko Okada, Takeshi Ihara, Takeo Hayashi, Eiichi Ogawa, Mosaburo Kainuma, Murata Masayuki, Jun Hayashi

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)

抄録

Objective: The most common screening tests for glucose intolerance are fasting plasma glucose (FPG) and glycated hemoglobin (HbA1c). Because it reflects the current status of hyperglycemia, urinary myo-inositol (UMI) may be useful. We evaluated UMI as a screening tool for glucose intolerance. Design and methods: A cross-sectional, community-based population study of 1057 Japanese residents. 173 with an FPG level between 5.5 and 6.9 mmol/L and an HbA1c under 6.5% had an oral glucose tolerance test. We measured UMI level before (fasting UMI) and 2 h after (2. h-UMI) glucose ingestion δ-UMI was defined as the difference between fasting UMI and 2 h-UMI. Results: δ-UMI, 2 h-UMI and HbA1c levels significantly increased as glucose intolerance worsened δ-UMI level was significantly positively correlated with 2 h-UMI level (r= 0.896, p< 0.001). Using cutoff levels from receiver operating characteristic (ROC) analyses, the sensitivity of δ-UMI (82.1%) and 2. h-UMI (79.3%) were higher than that of HbA1c (48.3%). The area under the ROC curve values for δ-UMI (0.903) and 2. h-UMI (0.891) were higher than that for HbA1c (0.785). Conclusions: 2. h-UMI is useful as a non-invasive screening of glucose intolerance.

元の言語英語
ページ(範囲)88-96
ページ数9
ジャーナルDiabetes Research and Clinical Practice
103
発行部数1
DOI
出版物ステータス出版済み - 1 1 2014

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Glucose Intolerance
Inositol
Fasting
Glucose
ROC Curve
Glycosylated Hemoglobin A
Glucose Tolerance Test

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

これを引用

The utility of urinary myo-inositol as a marker of glucose intolerance. / Ikezaki, Hiroaki; Furusyo, Norihiro; Okada, Kyoko; Ihara, Takeshi; Hayashi, Takeo; Ogawa, Eiichi; Kainuma, Mosaburo; Masayuki, Murata; Hayashi, Jun.

:: Diabetes Research and Clinical Practice, 巻 103, 番号 1, 01.01.2014, p. 88-96.

研究成果: ジャーナルへの寄稿記事

Ikezaki, Hiroaki ; Furusyo, Norihiro ; Okada, Kyoko ; Ihara, Takeshi ; Hayashi, Takeo ; Ogawa, Eiichi ; Kainuma, Mosaburo ; Masayuki, Murata ; Hayashi, Jun. / The utility of urinary myo-inositol as a marker of glucose intolerance. :: Diabetes Research and Clinical Practice. 2014 ; 巻 103, 番号 1. pp. 88-96.
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AU - Hayashi, Takeo

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AB - Objective: The most common screening tests for glucose intolerance are fasting plasma glucose (FPG) and glycated hemoglobin (HbA1c). Because it reflects the current status of hyperglycemia, urinary myo-inositol (UMI) may be useful. We evaluated UMI as a screening tool for glucose intolerance. Design and methods: A cross-sectional, community-based population study of 1057 Japanese residents. 173 with an FPG level between 5.5 and 6.9 mmol/L and an HbA1c under 6.5% had an oral glucose tolerance test. We measured UMI level before (fasting UMI) and 2 h after (2. h-UMI) glucose ingestion δ-UMI was defined as the difference between fasting UMI and 2 h-UMI. Results: δ-UMI, 2 h-UMI and HbA1c levels significantly increased as glucose intolerance worsened δ-UMI level was significantly positively correlated with 2 h-UMI level (r= 0.896, p< 0.001). Using cutoff levels from receiver operating characteristic (ROC) analyses, the sensitivity of δ-UMI (82.1%) and 2. h-UMI (79.3%) were higher than that of HbA1c (48.3%). The area under the ROC curve values for δ-UMI (0.903) and 2. h-UMI (0.891) were higher than that for HbA1c (0.785). Conclusions: 2. h-UMI is useful as a non-invasive screening of glucose intolerance.

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