The Wnt/β-catenin signaling pathway as a target in drug discovery

Fumi Takahashi-Yanaga, Toshiyuki Sasaguri

研究成果: ジャーナルへの寄稿評論記事

115 引用 (Scopus)

抄録

The cell signaling cascades provoked by Wnt proteins (the Wnt signaling pathways), which are well conserved through evolution, play crucial roles to maintain homeostasis of a variety of tissues such as skin, blood, intestine, and brain, as well as to regulate proliferation, morphology, motility, and fate of cells during embryonic development. Among these pathways, the signal transduction through β-catenin (the Wnt/β-catenin signaling pathway) has been most intensively studied because this signal regulates the expression of a number of genes essential for cell proliferation and differentiation and also this pathway is perturbed in a number of diseases such as cancers, bone diseases, and cardiovascular diseases. However, there is no therapeutic agents that can selectively modulate the Wnt/β-catenin signaling pathway, although some existing drugs (e.g., non-steroidal anti-inflammatory drugs, vitamins, and imatinib mesylate) have been suggested to inhibit this pathway. Here we provide an overview of the Wnt/β-catenin signaling pathway: its roles in physiology and pathology and the possibility as a target in development of new drugs.

元の言語英語
ページ(範囲)293-302
ページ数10
ジャーナルJournal of Pharmacological Sciences
104
発行部数4
DOI
出版物ステータス出版済み - 9 13 2007

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Catenins
Wnt Signaling Pathway
Drug Discovery
Wnt Proteins
Pharmaceutical Preparations
Bone Neoplasms
Bone Diseases
Essential Genes
Vitamins
Intestines
Embryonic Development
Cell Movement
Cell Differentiation
Signal Transduction
Homeostasis
Anti-Inflammatory Agents
Cardiovascular Diseases
Cell Proliferation
Pathology
Skin

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

これを引用

The Wnt/β-catenin signaling pathway as a target in drug discovery. / Takahashi-Yanaga, Fumi; Sasaguri, Toshiyuki.

:: Journal of Pharmacological Sciences, 巻 104, 番号 4, 13.09.2007, p. 293-302.

研究成果: ジャーナルへの寄稿評論記事

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