The WNT/MYB pathway suppresses KIT expression to control the timing of salivary proacinar differentiation and duct formation

Shinji Matsumoto, Takayuki Kurimoto, M. Mark Taketo, Shinsuke Fujii, Akira Kikuchi

研究成果: Contribution to journalArticle査読

22 被引用数 (Scopus)

抄録

Growth factor signaling is involved in the development of various organs, but how signaling regulates organ morphogenesis and differentiation in a coordinated manner remains to be clarified. Here, we show how WNT signaling controls epithelial morphogenetic changes and differentiation using the salivary gland as a model. Experiments using genetically manipulated mice and organ cultures revealed that WNT signaling at an early stage (E12-E15) of submandibular salivary gland (SMG) development inhibits end bud morphogenesis and differentiation into proacini by suppressing Kit expression through the upregulation of the transcription factor MYB, and concomitantly increasing the expression of distal progenitor markers. In addition, WNT signaling at the early stage of SMG development promoted end bud cell proliferation, leading to duct formation. WNT signaling reduction at a late stage (E16-E18) of SMG development promoted end bud maturation and suppressed duct formation. Thus, WNT signaling controls the timing of SMG organogenesis by keeping end bud cells in an undifferentiated bipotent state.

本文言語英語
ページ(範囲)2311-2324
ページ数14
ジャーナルDevelopment (Cambridge)
143
13
DOI
出版ステータス出版済み - 7 1 2016
外部発表はい

All Science Journal Classification (ASJC) codes

  • 分子生物学
  • 発生生物学

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