Therapeutic agents with AHR inhibiting and NRF2 activating activity for managing chloracne

Masutaka Furue, Yoko Fuyuno, Chikage Mitoma, Hiroshi Uchi, Gaku Tsuji

研究成果: Contribution to journalReview article査読

16 被引用数 (Scopus)

抄録

Chloracne is the major skin symptom caused by dioxin intoxication. Dioxin activates the aryl hydrocarbon receptor (AHR)–cytochrome p450 1A1 (CYP1A1) system, generates oxidative stress, and induces hyperkeratinization of keratinocytes and sebocytes leading to chloracne. Nuclear factor-erythroid 2-related factor-2 (NRF2) is a master switch that induces the expression of various antioxidative enzymes, such as heme oxygenase-1. Cinnamaldehyde is an antioxidant phytochemical that inhibits AHR–CYP1A1 signaling and activates the NRF2–antioxidative axis. The cinnamaldehyde-containing Kampo herbal medicine Keishibukuryogan is capable of improving chloracne in Yusho patients who are highly contaminated with dioxin. Agents with dual functions in promoting AHR–CYP1A1 inhibition and NRF2 activation may be useful for managing dioxin-related health hazards.

本文言語英語
論文番号90
ジャーナルAntioxidants
7
7
DOI
出版ステータス出版済み - 7 13 2018

All Science Journal Classification (ASJC) codes

  • 生化学
  • 生理学
  • 分子生物学
  • 臨床生化学
  • 細胞生物学

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