Therapeutic and clinical applications of nitroxide compounds

Benjamin P. Soule, Fuminori Hyodo, Ken Ichiro Matsumoto, Nicole L. Simone, John A. Cook, Murali C. Krishna, James B. Mitchell

研究成果: Contribution to journalReview article査読

103 被引用数 (Scopus)

抄録

Nitroxide compounds have been used for many years as biophysical tools, but only during the past 15-20 years have the many interesting biochemical interactions been discovered and harnessed for therapeutic applications. By modifying oxidative stress and altering the redox status of tissues, nitroxides have the ability to interact with and alter many metabolic processes. This interaction can be exploited for therapeutic and research use, including protection against ionizing radiation, as probes in functional magnetic resonance imaging, cancer prevention and treatment, control of hypertension and weight, and protection from damage resulting from ischemia/reperfusion injury. Although much remains to be done, many applications have been well studied, and some are presently being tested in clinical trials. The therapeutic and research uses of nitroxides are reviewed here, with a focus on the progress from initial development to modern, state-of-the art trials.

本文言語英語
ページ(範囲)1731-1743
ページ数13
ジャーナルAntioxidants and Redox Signaling
9
10
DOI
出版ステータス出版済み - 10 2007
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生理学
  • 生化学
  • 分子生物学
  • 臨床生化学
  • 細胞生物学

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