Therapeutic effects of hydrogen in animal models of Parkinson's disease

研究成果: Contribution to journalReview article査読

12 被引用数 (Scopus)

抄録

Since the first description of Parkinson's disease (PD) nearly two centuries ago, a number of studies have revealed the clinical symptoms, pathology, and therapeutic approaches to overcome this intractable neurodegenerative disease. 1-methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA) are neurotoxins which produce Parkinsonian pathology. From the animal studies using these neurotoxins, it has become well established that oxidative stress is a primary cause of, and essential for, cellular apoptosis in dopaminergic neurons. Here, we describe the mechanism whereby oxidative stress evokes irreversible cell death, and propose a novel therapeutic strategy for PD using molecular hydrogen. Hydrogen has an ability to reduce oxidative damage and ameliorate the loss of nigrostriatal dopaminergic neuronal pathway in two experimental animal models. Thus, it is strongly suggested that hydrogen might provide a great advantage to prevent or minimize the onset and progression of PD.

本文言語英語
論文番号307875
ジャーナルParkinson's Disease
DOI
出版ステータス出版済み - 2011

All Science Journal Classification (ASJC) codes

  • 神経科学(その他)
  • 臨床神経学
  • 精神医学および精神衛生

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