Therapeutic value of lymph node dissection for esophageal squamous cell carcinoma after neoadjuvant chemotherapy

Hiroshi Miyata, Makoto Yamasaki, Tomoki Makino, Yasuhiro Miyazaki, Tsuyoshi Takahashi, Yukinori Kurokawa, Kiyokazu Nakajima, Shuji Takiguchi, Masaki Mori, Yuichiro Doki

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)

抄録

Background and objectives The optimal extent of lymphadenectomy in patients with esophageal cancer is controversial. This study aimed to examine the therapeutic value of lymph node (LN) dissection for each LN station in patients with esophageal squamous cell carcinoma (ESCC) who receive neoadjuvant chemotherapy. Methods In 304 patients with ESCC who underwent neoadjuvant chemotherapy, Efficacy Index (EI) was calculated by multiplying the incidence of metastasis by the 3-year survival rate of patients with positive nodes for each LN station. Results Prognosis was better in responders to neoadjuvant chemotherapy than non-responders (3-year survival; 66.3% vs 48.1%, P = 0.0035). The total number of resected LNs did not affect survival although the number of positive LNs did. The number of resected LNs did not correlate with the number of metastatic LNs. Cardiac LN and recurrent nerve LN showed high EI, irrespective of tumor location. EI for each LN station did not vary according to the response to neoadjuvant therapy. Conclusions The present study showed that therapeutic value of each LN was not affected by preoperative chemotherapy. The location of resected LNs rather than the total number of resected LNs may be more important to maximize the survival benefit of lymphadenectomy. J. Surg. Oncol. 2015 111:60-65.

元の言語英語
ページ(範囲)60-65
ページ数6
ジャーナルJournal of Surgical Oncology
112
発行部数1
DOI
出版物ステータス出版済み - 1 1 2015
外部発表Yes

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Lymph Node Excision
Lymph Nodes
Drug Therapy
Survival
Therapeutics
Neoadjuvant Therapy
Esophageal Neoplasms
Esophageal Squamous Cell Carcinoma
Survival Rate
Neoplasm Metastasis
Incidence
Neoplasms

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

これを引用

Miyata, H., Yamasaki, M., Makino, T., Miyazaki, Y., Takahashi, T., Kurokawa, Y., ... Doki, Y. (2015). Therapeutic value of lymph node dissection for esophageal squamous cell carcinoma after neoadjuvant chemotherapy. Journal of Surgical Oncology, 112(1), 60-65. https://doi.org/10.1002/jso.23965

Therapeutic value of lymph node dissection for esophageal squamous cell carcinoma after neoadjuvant chemotherapy. / Miyata, Hiroshi; Yamasaki, Makoto; Makino, Tomoki; Miyazaki, Yasuhiro; Takahashi, Tsuyoshi; Kurokawa, Yukinori; Nakajima, Kiyokazu; Takiguchi, Shuji; Mori, Masaki; Doki, Yuichiro.

:: Journal of Surgical Oncology, 巻 112, 番号 1, 01.01.2015, p. 60-65.

研究成果: ジャーナルへの寄稿記事

Miyata, H, Yamasaki, M, Makino, T, Miyazaki, Y, Takahashi, T, Kurokawa, Y, Nakajima, K, Takiguchi, S, Mori, M & Doki, Y 2015, 'Therapeutic value of lymph node dissection for esophageal squamous cell carcinoma after neoadjuvant chemotherapy', Journal of Surgical Oncology, 巻. 112, 番号 1, pp. 60-65. https://doi.org/10.1002/jso.23965
Miyata, Hiroshi ; Yamasaki, Makoto ; Makino, Tomoki ; Miyazaki, Yasuhiro ; Takahashi, Tsuyoshi ; Kurokawa, Yukinori ; Nakajima, Kiyokazu ; Takiguchi, Shuji ; Mori, Masaki ; Doki, Yuichiro. / Therapeutic value of lymph node dissection for esophageal squamous cell carcinoma after neoadjuvant chemotherapy. :: Journal of Surgical Oncology. 2015 ; 巻 112, 番号 1. pp. 60-65.
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AB - Background and objectives The optimal extent of lymphadenectomy in patients with esophageal cancer is controversial. This study aimed to examine the therapeutic value of lymph node (LN) dissection for each LN station in patients with esophageal squamous cell carcinoma (ESCC) who receive neoadjuvant chemotherapy. Methods In 304 patients with ESCC who underwent neoadjuvant chemotherapy, Efficacy Index (EI) was calculated by multiplying the incidence of metastasis by the 3-year survival rate of patients with positive nodes for each LN station. Results Prognosis was better in responders to neoadjuvant chemotherapy than non-responders (3-year survival; 66.3% vs 48.1%, P = 0.0035). The total number of resected LNs did not affect survival although the number of positive LNs did. The number of resected LNs did not correlate with the number of metastatic LNs. Cardiac LN and recurrent nerve LN showed high EI, irrespective of tumor location. EI for each LN station did not vary according to the response to neoadjuvant therapy. Conclusions The present study showed that therapeutic value of each LN was not affected by preoperative chemotherapy. The location of resected LNs rather than the total number of resected LNs may be more important to maximize the survival benefit of lymphadenectomy. J. Surg. Oncol. 2015 111:60-65.

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