Thermally induced double proton transfer in GG and wobble GT base pairs: A possible origin of the mutagenic guanine

Adchara Padermshoke, Yukiteru Katsumoto, Ryuta Masaki, Misako Aida

研究成果: Contribution to journalArticle査読

26 被引用数 (Scopus)

抄録

Double proton transfer (DPT) reactions in three guanine-guanine (GG) dimers, a guanine-thymine wobble (wGT) base pair, and a model compound 4(3H)-pyrimidinone (k-PP) dimer have been investigated using ab initio MO calculations and liquid-phase infrared (IR) spectroscopy. The calculations suggest that the DPT processes in these dimers are energetically accessible. Temperature-dependent IR measurements of the model compound reveal that slight thermal energy can induce the DPT reaction, and hence the enol tautomer can result. The present study demonstrates a potential pathway for the generation of the mutagenic amino-enol form of guanine.

本文言語英語
ページ(範囲)232-236
ページ数5
ジャーナルChemical Physics Letters
457
1-3
DOI
出版ステータス出版済み - 5 20 2008
外部発表はい

All Science Journal Classification (ASJC) codes

  • 物理学および天文学(全般)
  • 物理化学および理論化学

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