Thermodynamic and structural characterization of the specific binding of Zn(II) to human protein DJ-1

Shinya Tashiro, Jose M.M. Caaveiro, Chun Xiang Wu, Quyen Q. Hoang, Kouhei Tsumoto

研究成果: Contribution to journalArticle査読

8 被引用数 (Scopus)

抄録

Mutations of DJ-1 cause familial Parkinson's disease (PD), although the role of DJ-1 in PD remains unresolved. Very recent reports have shown that DJ-1 interacts with copper ions. This evidence opens new avenues to understanding the function of DJ-1 and its role in PD. Herein, we report that Zn(II) binds to DJ-1 with great selectivity among the other metals examined: Mn(II), Fe(II), Co(II), Ni(II), and Cu(II). High-resolution X-ray crystallography (1.18 Å resolution) shows Zn(II) is coordinated to the protein by the key residues Cys106 and Glu18. These results suggest that DJ-1 may be regulated and/or stabilized by Zn(II).

本文言語英語
ページ(範囲)2218-2220
ページ数3
ジャーナルBiochemistry
53
14
DOI
出版ステータス出版済み - 4 15 2014
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biochemistry

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