Thermosensitive Polymer Biocompatibility Based on Interfacial Structure at Biointerface

Daiki Murakami, Yoko Kitahara, Shingo Kobayashi, Masaru Tanaka

研究成果: Contribution to journalArticle

7 引用 (Scopus)

抜粋

The interfacial structure of a thermosensitive biocompatible polymer, poly[2-(2-methoxyethoxy)ethyl methacrylate] (PMe2MA), at the polymer/phosphate-buffered saline (PBS) interface was investigated by atomic force microscopy. A number of nanometer scale protrusions appeared at 37 °C and disappeared at 22 °C, reversibly. This structural change occurred above the lower critical solution temperature of PMe2MA in PBS (19 °C), indicating that the formation of protrusions was explained by the microphase separation of polymer and water at the interfacial region. The protein adsorption and platelet adhesion onto PMe2MA interface were drastically restrained at 22 °C compared to that at 37 °C. Detachment of NIH3T3 cells accompanied by the dissipation of protrusions on the PMe2MA interface was also demonstrated. These results indicate that the protrusions act as the scaffold for the protein adsorption and cell adhesion.

元の言語英語
ページ(範囲)1591-1597
ページ数7
ジャーナルACS Biomaterials Science and Engineering
4
発行部数5
DOI
出版物ステータス出版済み - 5 14 2018

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering

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