Thermosensitive transparent semi-interpenetrating polymer networks for wound dressing and cell adhesion control

T. Thimma Reddy, Arihiro Kano, Atsushi Maruyama, Michiko Hadano, Atsushi Takahara

研究成果: ジャーナルへの寄稿記事

62 引用 (Scopus)

抄録

Thermosensitive, transparent, and flexible semi-interpenetrating polymer networks (semi-IPNs) composed of segmented polyurethane urea/ poly(N-isopropylacrylamide) (SPUU/ PNiPAAm) were new class of materials, which holds promise for its potential use as wound dressings. A series of semi-IPNs, obtained via thermal initiated polymerization of NiPAAm, were characterized by infrared spectroscopy (IR), nuclear magnetic resonance (NMR), dynamic viscoelastic measurements, wide-angle X-ray diffraction (WAXD), and mechanical properties. The resulting semi-IPNs were also investigated for their dynamic water contact angles, thermodynamic interaction parameters, in vitro drug release, and cell adhesion and detachment. The semi-IPNs with differing compositions possess good mechanical properties in both dry and hydrated states. In addition, NIH3T3 fibroblasts can attach to and detach from these semi-IPN films with varying temperature. In addition, these film extracts do not show significant cytotoxicity. Therefore, these materials have great potential for the construction of a new generation of dressings and cell transplantation for wound healing.

元の言語英語
ページ(範囲)1313-1321
ページ数9
ジャーナルBiomacromolecules
9
発行部数4
DOI
出版物ステータス出版済み - 4 1 2008

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Interpenetrating polymer networks
Cell adhesion
Bandages
Cell Adhesion
Polymers
Wounds and Injuries
Mechanical properties
Polyurethanes
Cell Transplantation
Fibroblasts
Cytotoxicity
Thermodynamics
Urea
X-Ray Diffraction
Polymerization
Wound Healing
Contact angle
Infrared spectroscopy
Magnetic Resonance Spectroscopy
Hot Temperature

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

これを引用

Thermosensitive transparent semi-interpenetrating polymer networks for wound dressing and cell adhesion control. / Reddy, T. Thimma; Kano, Arihiro; Maruyama, Atsushi; Hadano, Michiko; Takahara, Atsushi.

:: Biomacromolecules, 巻 9, 番号 4, 01.04.2008, p. 1313-1321.

研究成果: ジャーナルへの寄稿記事

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