Thioredoxin and ventricular remodeling

Tetsuro Ago, Junichi Sadoshima

研究成果: ジャーナルへの寄稿評論記事

61 引用 (Scopus)

抄録

Increasing bodies of evidence indicate that reactive oxygen species (ROS) produced by mitochondria and other sources play an essential role in mediating ventricular remodeling after myocardial infarction and the development of heart failure. Antioxidants scavenge ROS, thereby maintaining the reduced environment of cells and inhibiting ventricular remodeling in the heart. Thioredoxin not only functions as a major antioxidant in the heart but also interacts with important signaling molecules and transcription factors, thereby modulating various cellular functions. The activity of thioredoxin is regulated by a variety of mechanisms, such as transcription, localization, protein-protein interaction, and post-translational modification. In this review, we will summarize the cardiac effects of thioredoxin and the mechanisms by which thioredoxin mediates inhibition of ventricular remodeling.

元の言語英語
ページ(範囲)762-773
ページ数12
ジャーナルJournal of Molecular and Cellular Cardiology
41
発行部数5
DOI
出版物ステータス出版済み - 11 1 2006
外部発表Yes

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Thioredoxins
Ventricular Remodeling
Reactive Oxygen Species
Antioxidants
Post Translational Protein Processing
Mitochondria
Transcription Factors
Heart Failure
Myocardial Infarction
Proteins

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

これを引用

Thioredoxin and ventricular remodeling. / Ago, Tetsuro; Sadoshima, Junichi.

:: Journal of Molecular and Cellular Cardiology, 巻 41, 番号 5, 01.11.2006, p. 762-773.

研究成果: ジャーナルへの寄稿評論記事

Ago, Tetsuro ; Sadoshima, Junichi. / Thioredoxin and ventricular remodeling. :: Journal of Molecular and Cellular Cardiology. 2006 ; 巻 41, 番号 5. pp. 762-773.
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