Thioredoxin1 as a negative regulator of cardiac hypertrophy

Tetsuro Ago, Junichi Sadoshima

研究成果: ジャーナルへの寄稿記事

46 引用 (Scopus)

抄録

Excessive reactive oxygen species (ROS) play an important role in the development of cardiac hypertrophy. In contrast, antioxidants scavenge ROS, thereby maintaining the reduced environment of cells and inhibiting hypertrophy in the heart. Thioredoxin1 (Trx1) not only functions as a major antioxidant in the heart but also interacts with important signaling molecules and transcription factors, thereby attenuating cardiac hypertrophy. This review will discuss the molecular mechanisms by which Trx1 exerts antihypertrophic effects in the heart.

元の言語英語
ページ(範囲)679-687
ページ数9
ジャーナルAntioxidants and Redox Signaling
9
発行部数6
DOI
出版物ステータス出版済み - 6 1 2007

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Cardiomegaly
Reactive Oxygen Species
Antioxidants
Transcription Factors
Molecules

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

これを引用

Thioredoxin1 as a negative regulator of cardiac hypertrophy. / Ago, Tetsuro; Sadoshima, Junichi.

:: Antioxidants and Redox Signaling, 巻 9, 番号 6, 01.06.2007, p. 679-687.

研究成果: ジャーナルへの寄稿記事

Ago, Tetsuro ; Sadoshima, Junichi. / Thioredoxin1 as a negative regulator of cardiac hypertrophy. :: Antioxidants and Redox Signaling. 2007 ; 巻 9, 番号 6. pp. 679-687.
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