TY - JOUR
T1 - Three cases of synovial sarcoma of gastric wall
T2 - A case report and review of the literature
AU - Kuboyama, Yusuke
AU - Yamada, Yuichi
AU - Kohashi, Kenichi
AU - Toda, Yu
AU - Kawakami, Koji
AU - Kitahara, Daichi
AU - Nishiyama, Kenichi
AU - Hiraki, Yuka
AU - Oya, Masafumi
AU - Oda, Yoshinao
N1 - Funding Information:
Technical support for the experimental trials was provided by the following laboratory assistants: Motoko Tomita, Mami Nakamizo, Naomi Nino-Tateishi, Juri Godo, Kozue Ueno-Matsuda, Miwako Ishii, and Jumi Yahiro-Matsumoto. We also appreciate the technical assistance of The Research Support Center, Kyushu University Graduate School of Medical Sciences. This study was also supported by JSPS KAKEN Grant (Nos. 19H03444 , 17K15645 ).
Funding Information:
Technical support for the experimental trials was provided by the following laboratory assistants: Motoko Tomita, Mami Nakamizo, Naomi Nino-Tateishi, Juri Godo, Kozue Ueno-Matsuda, Miwako Ishii, and Jumi Yahiro-Matsumoto. We also appreciate the technical assistance of The Research Support Center, Kyushu University Graduate School of Medical Sciences. This study was also supported by JSPS KAKEN Grant (Nos. 19H03444, 17K15645).
Publisher Copyright:
© 2021 Elsevier GmbH
PY - 2021/3
Y1 - 2021/3
N2 - Synovial sarcoma (SS) is a malignant soft tissue neoplasm that occurs in various parts of the human body, but most commonly affects the extremities. Its diagnosis of synovial sarcoma often requires adjunctive techniques such as immunohistochemical staining and molecular studies, especially for synovial sarcoma at unusual locations. SS at a gastrointestinal location is exceedingly rare. We report here three cases of primary gastric synovial sarcoma. Malignant gastric mesenchymal tumor has many differential diagnoses other than synovial sarcoma, such as gastrointestinal stromal tumor (GIST), leiomyosarcoma, schwannoma, malignant peripheral nerve sheath tumor (MPNST) and so on. In our three cases, using reverse transcription polymerase chain reaction (RT-PCR) and direct sequencing, we detected an SS18-SSX1 fusion gene, which is specific to synovial sarcoma. In addition, we found the reduced expression of SMARCB1/INI1 in the tumor cells in two of the three cases. Through histopathological, immunohistochemical, and molecular analyses, we confirmed the diagnosis of primary gastric synovial sarcoma.
AB - Synovial sarcoma (SS) is a malignant soft tissue neoplasm that occurs in various parts of the human body, but most commonly affects the extremities. Its diagnosis of synovial sarcoma often requires adjunctive techniques such as immunohistochemical staining and molecular studies, especially for synovial sarcoma at unusual locations. SS at a gastrointestinal location is exceedingly rare. We report here three cases of primary gastric synovial sarcoma. Malignant gastric mesenchymal tumor has many differential diagnoses other than synovial sarcoma, such as gastrointestinal stromal tumor (GIST), leiomyosarcoma, schwannoma, malignant peripheral nerve sheath tumor (MPNST) and so on. In our three cases, using reverse transcription polymerase chain reaction (RT-PCR) and direct sequencing, we detected an SS18-SSX1 fusion gene, which is specific to synovial sarcoma. In addition, we found the reduced expression of SMARCB1/INI1 in the tumor cells in two of the three cases. Through histopathological, immunohistochemical, and molecular analyses, we confirmed the diagnosis of primary gastric synovial sarcoma.
UR - http://www.scopus.com/inward/record.url?scp=85100772235&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85100772235&partnerID=8YFLogxK
U2 - 10.1016/j.prp.2021.153352
DO - 10.1016/j.prp.2021.153352
M3 - Article
C2 - 33582394
AN - SCOPUS:85100772235
SN - 0344-0338
VL - 219
JO - Pathology Research and Practice
JF - Pathology Research and Practice
M1 - 153352
ER -