Three-dimensional molecular field analyses of octopaminergic agonists and antagonists for the locust neuronal octopamine receptor class 3

Akinori Hirashima, Takumi Nagata, Canping Pan, Eiichi Kuwano, Eiji Taniguchi, Morifusa Eto

研究成果: Contribution to journalArticle査読

5 被引用数 (Scopus)

抄録

The quantitative structure-activity relationship (QSAR) of a set of 70 octopaminergic agonists and 20 antagonists against octopamine receptor class 3 (OAR3) in locust nervous tissue was analyzed by molecular field analysis (MFA). MFA of these compounds evaluated effectively the energy between a probe and a molecular model at a series of points defined by a rectangular grid. Contour surfaces for the molecular fields are presented. These results provide useful information in the characterization and differentiation of octopaminergic receptor types and subtypes. (C) 2000 by Elsevier Science Inc.

本文言語英語
ページ(範囲)198-206
ページ数9
ジャーナルJournal of Molecular Graphics and Modelling
17
3-4
DOI
出版ステータス出版済み - 6 1999

All Science Journal Classification (ASJC) codes

  • 分光学
  • 物理化学および理論化学
  • コンピュータ グラフィックスおよびコンピュータ支援設計
  • 材料化学

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