Three-dimensional molecular-field analyses of octopaminergic agonists for the cockroach neuronal octopamine receptor

Akinori Hirashima, Masako Morimoto, Eiichi Kuwano, Morifusa Eto

研究成果: Contribution to journalArticle査読

13 被引用数 (Scopus)

抄録

The quantitative structure-activity relationship of a set of 40 octopaminergic agonists against receptor 2 in cockroach nervous tissue, was analyzed using molecular-field analysis (MFA). MFA on the study set of those compounds evaluated effectively the energy between a probe and a molecular model at a series of points defined by a rectangular grid. Contour surfaces for the molecular fields were presented and the results provided useful information in the characterization and differentiation of octopaminergic receptor.

本文言語英語
ページ(範囲)3753-3760
ページ数8
ジャーナルBioorganic and Medicinal Chemistry
11
17
DOI
出版ステータス出版済み - 8 15 2003

All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子医療
  • 分子生物学
  • 薬科学
  • 創薬
  • 臨床生化学
  • 有機化学

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