Three-dimensional visualization of intact mouse lung by synchrotron radiation CT

Toshihiro Sera, Naoto Yagi, Kentaro Uesugi

研究成果: Contribution to journalConference article査読

3 被引用数 (Scopus)

抄録

Airway is a complex branching structure of many compliant tubes, and then airway geometry and compliance have many biomechanical and clinical implications. In this study, we visualized an intact mouse lung without dehydration and fixation using synchrotron radiation CT at SPring-8 in Japan. The CT system consists of X-ray light source, a double crystal monochromator, a rotation stage and a high-resolution image detector. The angular projections were sequentially obtained during the sample rotation with the total scan shorter time than 15 min. The effective spatial resolution was 30 μm. Using this system, three-dimensional images of small airways and alveoli were obtained under physiological condition. Moreover, we visualized the same airways at FRC (functional residual capacity) and TLC (total lung capacity). The airway geometry deformed dramatically and the diameter expanded 1.2-1.7 times at TLC in comparison with at FRC. This deformation was larger for smaller airways. This system opens the way to new research of the pulmonary dynamics and physiological implications.

本文言語英語
ページ(範囲)1294-1297
ページ数4
ジャーナルAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
26 II
出版ステータス出版済み - 12 1 2004
外部発表はい
イベントConference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004 - San Francisco, CA, 米国
継続期間: 9 1 20049 5 2004

All Science Journal Classification (ASJC) codes

  • 信号処理
  • 生体医工学
  • コンピュータ ビジョンおよびパターン認識
  • 健康情報学

フィンガープリント

「Three-dimensional visualization of intact mouse lung by synchrotron radiation CT」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル