Three new medicagenic acid saponins from Polygala micrantha GUILL. & PERR.

Turibio Kuiate Tabopda, Anne Claire Mitaine-Offer, Tomofumi Miyamoto, Chiaki Tanaka, Bonaventure Tchaleu Ngadjui, Jean François Mirjolet, Olivier Duchamp, Marie Aleth Lacaille-Dubois

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

抄録

Three new medicagenic acid saponins, micranthosides A-C (1-3), were isolated from the roots of Polygala micrantha Guill. & Perr., along with six known presenegenin saponins. Their structures were elucidated on the basis of extensive 1D- and 2D-NMR experiments (1H, 13C, DEPT, COSY, TOCSY, NOESY, HSQC, and HMBC) and mass spectrometry as 3-O-β-D- glucopyranosylmedicagenic acid 28-[O-β-D-galactopyranosyl-(1→4)-O- β-D-xylopyranosyl-(1→4)-O-α-L-rhamnopyranosyl-(1→2) -β-D-fucopyranosyl] ester (1), 3-O-β-D-glucopyranosylmedicagenic acid 28-[O-6-O-acetyl-β-D-galactopyranosyl-(1→4)-O-β-D-xylopyranosyl- (1→4)-O-α-L-rhamnopyranosyl-(1→2)-β-D-fucopyranosyl] ester (2), and 3-O-{O-β-D-glucopyranosyl-(1→3)-O-[β-D-glucopyranosyl- (1→6)]-β-D-glucopyranosyl}medicagenic acid 28-{O-β-D- apiofuranosyl-(1→3)-O-β-D-xylopyranosyl-(1→4)-O-[β-D- apiofuranosyl-(1→3)]-O-α-L-rhamnopyranosyl-(1→2) -β-D-fucopyranosyl} ester (3). Compounds 1-3 were evaluated against HCT 116 and HT-29 human colon cancer cells, but they did not show any cytotoxicity.

元の言語英語
ページ(範囲)914-922
ページ数9
ジャーナルHelvetica Chimica Acta
94
発行部数5
DOI
出版物ステータス出版済み - 5 1 2011

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Polygala
Saponins
Esters
esters
acids
Acids
Cytotoxicity
Colonic Neoplasms
Mass spectrometry
Mass Spectrometry
Cells
Nuclear magnetic resonance
mass spectroscopy
cancer
nuclear magnetic resonance
medicagenic acid
Experiments

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Biochemistry
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

これを引用

Tabopda, T. K., Mitaine-Offer, A. C., Miyamoto, T., Tanaka, C., Ngadjui, B. T., Mirjolet, J. F., ... Lacaille-Dubois, M. A. (2011). Three new medicagenic acid saponins from Polygala micrantha GUILL. & PERR. Helvetica Chimica Acta, 94(5), 914-922. https://doi.org/10.1002/hlca.201000331

Three new medicagenic acid saponins from Polygala micrantha GUILL. & PERR. / Tabopda, Turibio Kuiate; Mitaine-Offer, Anne Claire; Miyamoto, Tomofumi; Tanaka, Chiaki; Ngadjui, Bonaventure Tchaleu; Mirjolet, Jean François; Duchamp, Olivier; Lacaille-Dubois, Marie Aleth.

:: Helvetica Chimica Acta, 巻 94, 番号 5, 01.05.2011, p. 914-922.

研究成果: ジャーナルへの寄稿記事

Tabopda, TK, Mitaine-Offer, AC, Miyamoto, T, Tanaka, C, Ngadjui, BT, Mirjolet, JF, Duchamp, O & Lacaille-Dubois, MA 2011, 'Three new medicagenic acid saponins from Polygala micrantha GUILL. & PERR.', Helvetica Chimica Acta, 巻. 94, 番号 5, pp. 914-922. https://doi.org/10.1002/hlca.201000331
Tabopda, Turibio Kuiate ; Mitaine-Offer, Anne Claire ; Miyamoto, Tomofumi ; Tanaka, Chiaki ; Ngadjui, Bonaventure Tchaleu ; Mirjolet, Jean François ; Duchamp, Olivier ; Lacaille-Dubois, Marie Aleth. / Three new medicagenic acid saponins from Polygala micrantha GUILL. & PERR. :: Helvetica Chimica Acta. 2011 ; 巻 94, 番号 5. pp. 914-922.
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abstract = "Three new medicagenic acid saponins, micranthosides A-C (1-3), were isolated from the roots of Polygala micrantha Guill. & Perr., along with six known presenegenin saponins. Their structures were elucidated on the basis of extensive 1D- and 2D-NMR experiments (1H, 13C, DEPT, COSY, TOCSY, NOESY, HSQC, and HMBC) and mass spectrometry as 3-O-β-D- glucopyranosylmedicagenic acid 28-[O-β-D-galactopyranosyl-(1→4)-O- β-D-xylopyranosyl-(1→4)-O-α-L-rhamnopyranosyl-(1→2) -β-D-fucopyranosyl] ester (1), 3-O-β-D-glucopyranosylmedicagenic acid 28-[O-6-O-acetyl-β-D-galactopyranosyl-(1→4)-O-β-D-xylopyranosyl- (1→4)-O-α-L-rhamnopyranosyl-(1→2)-β-D-fucopyranosyl] ester (2), and 3-O-{O-β-D-glucopyranosyl-(1→3)-O-[β-D-glucopyranosyl- (1→6)]-β-D-glucopyranosyl}medicagenic acid 28-{O-β-D- apiofuranosyl-(1→3)-O-β-D-xylopyranosyl-(1→4)-O-[β-D- apiofuranosyl-(1→3)]-O-α-L-rhamnopyranosyl-(1→2) -β-D-fucopyranosyl} ester (3). Compounds 1-3 were evaluated against HCT 116 and HT-29 human colon cancer cells, but they did not show any cytotoxicity.",
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