TY - JOUR
T1 - Thrombocytosis in asplenia syndrome with congenital heart disease
T2 - A previously unrecognized risk factor for thromboembolism
AU - Yamamura, Kenichiro
AU - Joo, Kunitaka
AU - Ohga, Shouichi
AU - Nagata, Hazumu
AU - Ikeda, Kazuyuki
AU - Muneuchi, Jun
AU - Watanabe, Mamie
AU - Hara, Toshiro
PY - 2013/9/1
Y1 - 2013/9/1
N2 - Background: Thrombocytosis and thromboembolic complications occur after splenectomy. However, there is no previous report investigating the presence of thrombocytosis and its association with thromboembolic events in patients having asplenia syndrome with congenital heart disease. Methods: Enrolled were 161 consecutive patients with functionally single ventricle who underwent cardiac catheterization between 1997 and 2010. They were divided into two groups: patients having asplenia (Group A, n = 46) and patients having no asplenia (Group B, n = 115). Aspirin therapy was employed in all patients after surgical interventions except for pulmonary artery banding. We retrospectively reviewed the platelet counts at each seven stage of cardiac catheterization (for pre- and postoperative evaluation of the first palliation, Glenn operation, and Fontan operation, and for late evaluation after Fontan operation), incidence of thromboembolic events, and other possible risk factors for thromboembolism. Results: The median platelet counts in Group A were consistently higher than those in Group B at any of the seven stages of cardiac catheterizations (p < 0.002). The incidence of thromboembolic complications was also higher in Group A than that in Group B (28% vs. 10%, p = 0.030). Univariate and multivariate logistic regression analyses showed that a platelet count of more than 550 × 109/L at the first cardiac catheterization was associated with thromboembolic complications (Odds ratio 3.17; p = 0.046). Conclusions: Persistent thrombocytosis is present in patients with asplenia syndrome. It may greatly contribute to the development of thromboembolism during the management of congenital heart disease than expected.
AB - Background: Thrombocytosis and thromboembolic complications occur after splenectomy. However, there is no previous report investigating the presence of thrombocytosis and its association with thromboembolic events in patients having asplenia syndrome with congenital heart disease. Methods: Enrolled were 161 consecutive patients with functionally single ventricle who underwent cardiac catheterization between 1997 and 2010. They were divided into two groups: patients having asplenia (Group A, n = 46) and patients having no asplenia (Group B, n = 115). Aspirin therapy was employed in all patients after surgical interventions except for pulmonary artery banding. We retrospectively reviewed the platelet counts at each seven stage of cardiac catheterization (for pre- and postoperative evaluation of the first palliation, Glenn operation, and Fontan operation, and for late evaluation after Fontan operation), incidence of thromboembolic events, and other possible risk factors for thromboembolism. Results: The median platelet counts in Group A were consistently higher than those in Group B at any of the seven stages of cardiac catheterizations (p < 0.002). The incidence of thromboembolic complications was also higher in Group A than that in Group B (28% vs. 10%, p = 0.030). Univariate and multivariate logistic regression analyses showed that a platelet count of more than 550 × 109/L at the first cardiac catheterization was associated with thromboembolic complications (Odds ratio 3.17; p = 0.046). Conclusions: Persistent thrombocytosis is present in patients with asplenia syndrome. It may greatly contribute to the development of thromboembolism during the management of congenital heart disease than expected.
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U2 - 10.1016/j.ijcard.2012.06.009
DO - 10.1016/j.ijcard.2012.06.009
M3 - Article
C2 - 22727971
AN - SCOPUS:84883261776
VL - 167
SP - 2259
EP - 2263
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
IS - 5
ER -